Inos CD14 - Search

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nih.gov
https://pmc.ncbi.nlm.nih.gov › articles
Microglial CD14 Activated by iNOS Contributes to …
The above results suggested that iNOS can activate microglial CD14 to contribute to neuroinflammation in cerebral ischemia. NF-κB, a transcription factor, not only plays a crucial …
PubMed
https://pubmed.ncbi.nlm.nih.gov
Microglial CD14 activated by iNOS contributes to ... - PubMed
Apr 19, 2013 · These results suggest that the upregulation of TNF-α production in ischemic stroke is partially through increasing iNOS, and then CD14 expression leading to the activation of the …
- Author: Mian Zhou, Christie M. Wang, Weng Lang Yang, Ping Wang
- Publish Year: 2013
ScienceDirect
https://www.sciencedirect.com › science › article › pii
CD14: Biology and role in the pathogenesis of disease
Aug 1, 2019 · For instance, microglial CD14 activated by iNOS contributes to neuroinflammation in cerebral ischemia, GM-CSF promotes neuroinflammation through increasing the expression …
- Author: Zhenghao Wu, Zhenxiong Zhang, Zehua Lei, Ping Lei
- Publish Year: 2019
Studies of Inos CD14
PubMed
Microglial CD14 activated by iNOS contributes to neuroinflammation in cerebral ischemia
Stroke is one of the most frequent causes of death and disability worldwide. Cerebral ischemia is the major insult of stroke and induces acute inflammation by triggering excessive production of proinflammatory cytokines, leading to the exacerbation of primary brain damage. Toll-like receptor (TLR)- ...
Author: Mian Zhou
Published: 2013/04/19
Keywords: National In…
ScienceDirect
CD14: Biology and role in the pathogenesis of disease
Human monocyte differentiation antigen CD14 is a pattern recognition receptor (PRR) that enhances innate immune responses. CD14 was first identified as a marker of monocytes to signal intracellular responses upon bacterial encounters. Given the absence of an intracellular tail, CD14 was doubted to h...
Published: 2019/08/01
Cited By: 0
Keywords: CD14; Inna…
PubMed
Increased CD14+HLA-DR-/low Myeloid-Derived Suppressor Cells Correlate With Disease Severity in Systemic Lupus Erythematosus Patients in an iNOS-Dependent Manner
Myeloid-derived suppressor cells (MDSCs) comprise of a population of cells, which suppress the innate and adaptive immune system via different mechanisms. MDSCs are accumulated under pathological conditions. The present study aimed to clarify the pathological role of MDSCs in systemic lupus erythema...
Author: Zhitao Wang
Published: 2019/05/29
Keywords: SLE; disea…
National Center for Biotechnology Information
Microglial CD14 Activated by iNOS Contributes to Neuroinflammation in Cerebral Ischemia
Stroke is one of the most frequent causes of death and disability worldwide. Cerebral ischemia is the major insult of stroke and induces acute inflammation by triggering excessive production of proinflammatory cytokines, leading to the exacerbation of primary brain damage. Toll-like receptor (TLR)- ...
Author: Mian Zhou, Ch…
Published: 2013/04/04
DOI: 10.1016/j.brainres…
National Center for Biotechnology Information
Deficiency of the pattern-recognition receptor CD14 protects against joint pathology and functional decline in a murine model of osteoarthritis
Objective CD14 is a monocyte/macrophage pattern-recognition receptor that modulates innate inflammatory signaling. Soluble CD14 levels in knee OA synovial fluids are associated with symptoms and progression of disease. Here we investigate the role of this receptor in development of OA using a murin...
Author: Nisha Samba…
Published: 2018
Publication: PLoS On…
ScienceDirect
Induced nitric oxide synthase (iNOS) and indoleamine 2,3-dioxygenase (IDO) detection in circulating monocyte subsets from Brazilian patients with Dengue-4 virus
Among viral diseases transmitted by mosquitoes, dengue is characterized by its rapid dispersion around the world. Dengue severity is associated to a cytokine “storm” leading to vascular hemorrhagic manifestations, plasma leakage and shock, but also producing viral clearance. Macrophage/monocyte acti...
Published: 2017/06/01
Cited By: 0
Page Count: 11
ScienceDirect
Research Report Microglial CD14 activated by iNOS contributes to neuroinflammation in cerebral ischemia
Stroke is one of the most frequent causes of death and disability worldwide. Cerebral ischemia is the major insult of stroke and induces acute inflammation by triggering excessive production of proinflammatory cytokines, leading to the exacerbation of primary brain damage. Toll-like receptor (TLR)- ...
Published: 2013/04/19
Cited By: 0
Keywords: MCAO midd…
ScienceDirect
"Lipopolysaccharide-induced animal models for neuroinflammation – An overview."
Neuroinflammation is a pathological mechanism contributing to neurodegenerative diseases. For in-depth studies of neuroinflammation, several animal models reported reproducing behavioral dysfunctions and cellular pathological mechanisms induced by brain inflammation. One of the most popular models o...
Published: 2024/02/15
Cited By: 0
Keywords: Neuroinfla…
PubMed
Multifaceted role of CD14 in innate immunity and tissue homeostasis
CD14 is a co-receptor of Toll-like receptor (TLR)- 4, with a critical role in innate immune responses. CD14 recognizes bacterial lipopolysaccharides, pathogen-, and damage-associated molecular patterns, thereby facilitating inflammatory immune responses. In addition to its well-established associati...
Author: Kunhee Na
Published: 2023/12
Keywords: Apoptosis; …
nih.gov
https://pmc.ncbi.nlm.nih.gov › articles
LPS and IL-1 differentially activate mouse and human …
Mouse astrocyte CD14 (cell-associated and soluble) was potently upregulated by LPS. Silencing TLR4 or CD14 by siRNA suppressed LPS responses in mouse astrocytes. In vivo, astrocytes in LPS-injected mouse brains also expressed …
nih.gov
https://pmc.ncbi.nlm.nih.gov › articles
Arginase1 deficiency in monocytes/macrophages up-regulates …
Using human skin from contact dermatitis patients and a mouse model of CHS, we find that hapten allergens disrupt the Arginase1 (Arg1) and inducible nitric oxide synthase (iNOS or …
PubMed
https://pubmed.ncbi.nlm.nih.gov
Increased CD14 + HLA-DR -/low Myeloid-Derived Suppressor …
May 29, 2019 · An elevated level of M-MDSCs was positively correlated with the disease severity in SLE patients and an immunosuppressive role was exerted in an iNOS-dependent manner. …
People also ask
How does CD14 affect vascular intima?
These findings together suggest that CD14 can not only contribute to form inflammation milieu within vascular intima via enhancing the response of cells to atherosclerosis-related factors but also promote the formation of atherosclerotic lesion directly via modulating the fate of inflammatory cells and smooth muscle cells.
CD14: Biology and role in the pathogenesis of disease
sciencedirect.com
How does CD14 affect atherosclerosis?
Atherosclerosis is characterized by a chronic arterial wall inflammation. Disturbed immune responses and aberrant lipid metabolism are involved in its pathogenesis . Quite a few of studies have indicated a vital role of the interactions between CD14 and many atherosclerosis-related factors in the development of atherosclerosis.
CD14: Biology and role in the pathogenesis of disease
sciencedirect.com
How does CD14 affect lysosome response?
CD14 also acts as a key receptor for secreted GRP78 to promote internalization of TLR4 to lysosomes, and therefore induces a TLR4 deficiency that renders cells poorly responsive to subsequent encounters with LPS .
CD14: Biology and role in the pathogenesis of disease
sciencedirect.com
What role does CD14 play in sepsis?
Critical role of CD14 for production of proinflammatory cytokines and cytokine inhibitors during sepsis with failure to alter morbidity or mortality. Infect. Immun. 2001;69:2099–2106.
Microglial CD14 Activated by iNOS Contributes to Neuroinflammation i…
ncbi.nlm.nih.gov
Why is CD14 required by exogenous Hsp70?
In the human monocytes, CD14 is required by exogenous HSP70 to elicit a rapid intracellular calcium flux and to induce proinflammatory cytokine production . Stress-inducible endogenous HSP70 from human myocardial cells are released into the circulation and provoke similar effects with CD14 involved .
CD14: Biology and role in the pathogenesis of disease
sciencedirect.com
How does CD14 affect macrophages?
CD14 can even bind to minimally modified LDL and heighten the F-actin response of macrophages to minimally modified LDL, which impairs their ability of cytoskeleton rearrangement for clearing apoptotic cells within atherosclerotic lesion . Anti-CD14 antibody reduces electronegative LDL-induced release of MCP1, IL6 and IL10 by 75–80% .
CD14: Biology and role in the pathogenesis of disease
sciencedirect.com
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National Center for Biotechnology Information
https://www.ncbi.nlm.nih.gov › pmc › articles
Microglial CD14 Activated by iNOS Contributes to …
Apr 4, 2013 · The above results suggested that iNOS can activate microglial CD14 to contribute to neuroinflammation in cerebral ischemia. NF-κB, a transcription factor, not only plays a crucial …
National Center for Biotechnology Information
https://www.ncbi.nlm.nih.gov › pmc › articles
Deficiency of the pattern-recognition receptor CD14 protects …
Nov 28, 2018 · CD14 is a monocyte/macrophage pattern-recognition receptor that modulates innate inflammatory signaling. Soluble CD14 levels in knee OA synovial fluids are associated …
qiagen.com
https://geneglobe.qiagen.com › ... › inos-sig…
iNOS Signaling | GeneGlobe - Qiagen
Cell wall components of bacteria and fungi trigger the innate immune signaling cascade, leading to expression of iNOS. Lipopolysaccharide (LPS), a component of the wall of gram-negative bacteria, binds to LBP, which delivers LPS to the …
ResearchGate
https://www.researchgate.net › figure › Mea…
Mean fluorescence intensity (MFI) of iNOS or IDO …
Mean fluorescence intensity (MFI) of iNOS or IDO within CD14 + cells in dengue patients according to monocyte subsets. PBMCs from DENV infected patients and healthy controls were labeled with...
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