Indican is a colourless organic compound, soluble in water, naturally occurring in Indigofera plants. It is a precursor of indigo dye. [1]

Indican is a toxic metabolite derived from dietary proteins and tryptophan. In the intestine, proteins and tryptophan are converted to indole by tryptophanase-expressing organisms. In the liver, indole is hydroxylated to form indoxyl and indoxyl is sufated to produce indican.

Indican is an indole produced when bacteria in the intestine act on the amino acid, tryptophan. Most indoles are excreted in the feces. The remainder is absorbed, metabolized by the liver, and excreted as indicanin the urine. Indican normally appears in urine only at low levels, since it’s not normally produced in the cells of your body.

The most extensively studied of the uremic indoles is indoxyl sulfate, or indican. Indican is produced from tryptophan in a manner reminiscent of the production of p-cresol sulfate from tyrosine and phenylalanine.

A substance occurring in the urine of mammals and also in blood plasma as the normal metabolite of tryptophan. An increased urinary excretion of indican is seen in Hartnup disease from the bacterial degradation of unabsorbed tryptophan.

Nov 14, 2018 · Indican is an indole produced when bacteria in the intestine act on the amino acid, tryptophan. Most indoles are excreted in the feces. The remainder is absorbed, metabolized by the liver, and excreted as indican in the urine. Indican normally appears in urine only at low levels, since it’s not normally produced in the cells of your body ...

This technology, outlined in a study published today in Nature Communications, could enable large-scale production and application of indican, a molecule related to indigo, without toxic...

Indican, the β-O-glucoside of the indigo precursor indoxyl, is the natural storage form of indigo in indigo-producing plants 7. It has been suggested as an environmentally mild blue denim dyeing agent since indican dyeing would eliminate reducing agents while still ending as indigo in …

Indican is a byproduct of tryptophan putrefaction by microbes in the gut. Accumulated levels of indican in the urine suggest higher levels of tryptophan putrefaction from gastrointestinal dysbiosis or malabsorption. Production of indican occurs when tryptophan creates indoles in the colon.

In this study, the effects of indican, indigo, indoxyl, and indirubin were evaluated by flow cytometry using appropriate fluorescent probes in rat thymic lymphocytes. Among the dyes analyzed, indirubin exerted distinct cellular activities.