The IMQ-induced psoriasis mouse model recapitulates several features of skin inflammatory diseases similar to human psoriatic inflammation. These characterized features include increased thickening of the epidermal layer, elongation of rete-like …

Jun 6, 2023 · To determine the response of AREG-UTR animals to a pro-inflammatory skin challenge, topical imiquimod (IMQ) or vehicle cream was applied to dorsal and tail skin. IMQ increased dorsal skin thickness similarly in both AREG-UTR and wild type mice (1.7- and 2.2-fold vs vehicle, P < 0.001 each), but had no such effect on tail skin.

Mar 9, 2017 · IMQ is a Toll-like receptor (TLR7/8) agonist that can be applied to mouse skin to elicit erythema, scaling, keratinocyte (KC) proliferation with acanthosis, altered KC differentiation (parakeratosis), and a dermal infiltrate that includes T cells [3].

Apr 28, 2023 · To confirm the pathological observations of Mincle-expressing macrophages in patients with psoriasis, we established a psoriasis-like mouse model by topically applying miquimod (IMQ) to the skin...

Apr 2, 2024 · We conducted a single adoptive transfer of DNT into an imiquimod (IMQ)-induced psoriasis mouse model through tail vein injection. The skin inflammation and IL-17A producing γδ T cells were evaluated.

Sep 29, 2017 · We examined whether macrophages are activated in the skin of imiquimod (IMQ)-treated mice, a model for IL-17A-induced psoriasis-like skin inflammation, and flaky-tail (Flg ft) mice, a model for...

Methods: Skin specimens were biopsied from patients with psoriasis vulgaris at the active stage, or from the tail skin of Dct-LacZ mice with imiquimod (IMQ)-induced psoriasiform dermatitis. Cultured keratinocytes (KCs), MCs, and human skin explants were used in this study.

Jun 30, 2022 · IMQ is an agonist of Toll-like receptors (TLR) 7 and 8, used to treat warts, and has been widely used to induce psoriasis-like skin inflammation . Several studies have shown that MSCs and exosomes derived from MSCs can effectively improve psoriasis-like skin lesions in mouse models [ 37 – 39 ].

We conducted adoptive transfer of CD4 T cell converted DNT cells (cDNT) into the IMQ-induced psoriasis mouse model through tail vein injection. Following cDNT treatment, there was a reduction in the inflammatory response in mouse skin, characterized by decreased skin folds, scales, and red patches.

Genome-wide association studies have found that polymorphisms in genes for IL-23 and its receptor are important in psoriasis, and blocking IL-23 is an effective therapy in the disease. The use of Aldara ™, a cream that contains the TLR7 and TLR8 agonist imiquimod (IMQ), was found to exacerbate psoriasis in some patients with pre-existing ...