The IL-4, IL-13 and IL-31 pathways in atopic dermatitis
The IL-4, IL-13 and IL-31 inflammatory pathways have been identified as hallmark features in the pathogenesis of the disease, contributing uniquely and synergistically to immune and barrier …
IL-4 impairs wound healing potential in the skin by repressing ...
Keratinocyte gene expression is critically shaped by IL-4, altering cell fate decisions likely important for the clinical manifestations and pathology of allergic skin disease. Keywords: …
IL-4 regulates skin homeostasis and the predisposition towards …
IL-4-deficiency protects Stat6VT transgenic mice from the development of allergic skin inflammation and decreased recovery time in barrier function following skin irritation, with a …
An Interleukin-4 and Interleukin-13 Induced Atopic Dermatitis …
Type 2 inflammation, mediated by interleukin (IL)-4 and IL-13, plays an important role in AD. In this study, full-thickness human skin equivalents consisting of human-derived cells were …
Common and different roles of IL-4 and IL-13 in skin allergy and ...
Purpose of review: This review summarizes the mode of action of IL-4 and IL-13 in skin allergy, upcoming therapeutics and depicts key outcomes of the latest clinical trials. Recent findings: …
Regulation of Filaggrin, Loricrin, and Involucrin by IL-4, IL-13, IL ...
Jul 29, 2020 · Atopic dermatitis (AD) is an eczematous, pruritic skin disorder with extensive barrier dysfunction and elevated interleukin (IL)-4 and IL-13 signatures. The barrier dysfunction …
Healing action of Interleukin-4 (IL-4) in acute and chronic ...
Jan 1, 2025 · Studies have shown that during skin repair, IL-4 activates macrophages to secrete resistin-like alpha (RELMα) and up-regulate lysyl hydroxylase 2, thereby regulating collagen …
IL-4 Regulates Skin Homeostasis and the Predisposition toward …
Mar 15, 2010 · IL-4 deficiency protects Stat6VT transgenic mice from the development of allergic skin inflammation and decreased recovery time in barrier function following skin irritation, with …
IL-4 acts on skin-derived dendritic cells to promote the T
IL-4 acts on skin DCs that capture antigen and migrate to dLNs to promote their capacity for T H 2 polarization and drive allergic skin inflammation. Atopic dermatitis (AD) is the most common …
Overexpression of IL-4 Alters the Homeostasis in the Skin
May 1, 2002 · We studied the structural, phenotypic, and functional properties of skin and individual skin cell populations in tg mice overexpressing IL-4 ubiquitously (Erb et al, 1994), …