IL-33/ST2 signalling is involved in T-cell mediated immune responses, but more recently, an unanticipated role in cardiovascular disease has been demonstrated.

The IL-33 receptor ST2, encoded by IL1RL1, is expressed as both a membrane-anchored receptor (ST2L) activated by IL-33, and as a soluble variant (sST2) that exhibits anti …

Dec 11, 2023 · The IL-33-ST2 signaling pathway plays a pro-inflammatory role by activating the type 2 inflammatory response, producing type 2 cytokines and chemokines. Elevated levels of …

Sep 22, 2020 · Here we demonstrate a protective function for the IL-33-ST2 axis in bronchial epithelial repair, and implicate ST2 in myeloid cell differentiation. ST2 deficiency in mice leads …

In this review, we will call ST2 as the IL-33 receptor or Ilr1rl gene product. ST2 has two main splice variants due to differential promoter binding: a membrane-bound form (ST2), which …

Apr 27, 2021 · IL33 (interleukin 33) resides in the nucleus in normal cells. Upon cell injury, IL33 is released as a nuclear alarmin and binds to its receptor ST2 (interleukin 1 receptor-like 1) on …

Interleukin-33 (IL-33) is a nuclear cytokine critically important in tissue remodeling and allergic airway diseases that signals through the receptor ST2.

IL-33/ST2 not only represents a promising cardiovascular biomarker but also a novel mechanism of intramyocardial fibroblast-cardiomyocyte communication that may prove to be a therapeutic …

IL-33 signals through ST2 receptor and promotes inflammation by activating downstream pathways culminating in the production of pro-inflammatory mediators such as IL-1β, TNF-α, …

Jun 5, 2019 · Here, we reveal that IL-33 signaling promotes CRC by changing the phenotype of Tregs. In mice with CRC, tumor-infiltrating Tregs preferentially upregulate IL-33 receptor …