IL12RB2 is its human gene. [5] IL12RB2 orthologs [6] have been identified in all mammals for which complete genome data are available. The protein encoded by this gene is a type I …

Mar 30, 2025 · IL12RB2 (Interleukin 12 Receptor Subunit Beta 2) is a Protein Coding gene. Diseases associated with IL12RB2 include Dyskeratosis Congenita, Autosomal Dominant 6 …

IL12RB2 is a prognostic marker in Head and neck squamous cell carcinoma, Kidney renal papillary cell carcinoma, Ovary serous cystadenocarcinoma, Rectum adenocarcinoma

data clearly support the IL12RB2 genetic association with systemic sclerosis (SSc), and suggest a relevant role of the interleukin 12 signaling pathway in SSc pathogenesis. Our results support …

Consistently, neoplastic immune evasion strategies from IL-12-induced anti-tumor immunity exist, since B cells in various chronic lymphoproliferative disorders may silence the gene for IL …

Dec 22, 2020 · When expressed in COS-7 cells, IL12RB2 exists as a disulfide-linked oligomer with an apparent monomeric molecular mass of 130 kD. Functional studies indicated that high …

Sep 18, 2024 · Title: An ankylosing spondylitis-associated genetic variant in the IL23R-IL12RB2 intergenic region modulates enhancer activity and is associated with increased Th1-cell …

Taken together, these data show that there is differential regulation of IL-12Rbeta2 expression by IFN-alpha and IFN-gamma on human T and NK cells. The biological activities of IL-12 are …

Jan 4, 2025 · IL12RB2 interleukin 12 receptor subunit beta 2 Gene ID: 3595, updated on 4-Jan-2025 Gene type: protein coding. See all available tests in GTR for this gene; Go to complete …

Dec 31, 2013 · Development of a model to study the effect of amino acid changes in IL-12Rβ2. The model can distinguish between deleterious, intermediate and innocuous effects. The IL …