Interleukin 11 (IL-11 or adipogenesis inhibitory factor[5]) is a protein that in humans is encoded by the IL11 gene. [6] IL-11 is a cytokine that was first isolated in 1990 from bone marrow -derived fibrocyte -like stromal cells.

Jul 17, 2024 · Deletion of Il11 or Il11ra1 protects against metabolic decline, multi-morbidity and frailty in old age. Administration of anti-IL-11 to 75-week-old mice for 25 weeks improves metabolism and...

Interleukin 11 (IL11) is an elusive member of the IL6 family of cytokines. While initially thought to be a haematopoietic and cytoprotective factor, more recent data show instead that IL11 is redundant for haematopoiesis and toxic.

Mar 30, 2025 · IL11 (Interleukin 11) is a Protein Coding gene. Diseases associated with IL11 include Hemorrhagic Cystitis and Plasmacytoma. Among its related pathways are MIF Mediated Glucocorticoid Regulation and TGF-Beta Pathway. Gene Ontology (GO) annotations related to this gene include cytokine activity and interleukin-11 receptor binding.

Jun 1, 1997 · Initially characterized as a hematopoietic cytokine with thrombopoietic activity, IL-11 has now been shown to be expressed and have activity in multiple other tissues, including brain, spinal cord neurons, gut, and testis. Yet to date, the physiologic role of …

Dec 1, 2023 · Interleukin- (IL)-11 is a cytokine involved in hematopoiesis, cancer metastasis, and inflammation. IL-11 belongs to the IL-6 cytokine family, binding to the complex of receptors glycoprotein gp130 and the ligand-specific-receptor subunits (IL-11Rα or …

We review the role of interleukin-11 (IL11), a stromal-cell derived pleiotropic cytokine with profibrotic and cellular remodeling properties, as a potential biomarker in NSCLC.

Dec 1, 2020 · Interleukin (IL)-11 evolved as part of the innate immune response. In the human lung, IL-11 upregulation has been associated with viral infections and a range of fibroinflammatory diseases,...

Nov 20, 2023 · Interleukin (IL-)11, an IL-6 family cytokine, has pivotal roles in autoimmune diseases, fibrotic complications, and solid cancers. Despite intense therapeutic targeting efforts, structural...

Jan 1, 2022 · Interleukin-11 (IL-11) is a cytokine that has been strongly implicated in the pathogenesis of fibrotic diseases and solid malignancies. Elevated IL-11 expression is also associated with several non-malignant inflammatory diseases where its function remains less well-characterized.