The IL-5 receptor (IL-5R) belongs to the type I cytokine receptor family and is a heterodimer composed of two polypeptide chains, one α subunit, which binds IL-5 and confers upon the …

Jan 8, 2019 · Anti-interleukin-5 therapy is approved for patients with refractory asthma with an eosinophilic phenotype. The severe asthma care team at Mayo Clinic has expertise in …

IL-5Rα expression in activated B cells is regulated by a complex of transcription factors including E12, E47, Sp1, c/EBPβ, and Oct2. IL-5 signals are transduced through JAK–STAT, Btk, and …

IL-5 binds to the α subunit of IL-5 receptor (IL-5Rα), thereby inducing its interaction with βc subunits and the following activation of a complex intracellular signaling network, consisting of …

Nov 11, 2019 · Unlike the other anti‒IL-5 monoclonal antibodies which exert an indirect effect on eosinophils, benralizumab, an afucosylated IgG 1 kappa antibody directed against the α …

Oct 9, 2009 · Over-expression of IL-5 significantly increases eosinophil numbers and antibody levels in vivo. Conversely, mice lacking a functional gene for IL-5 or the IL-5 receptor alpha …

Monoclonal antibodies that target the eosinophilic inflammatory pathways (IL‐5R and IL‐5), namely mepolizumab, reslizumab, and benralizumab, are effective and safe for severe …

The monoclonal antibodies mepolizumab and reslizumab target the ligand IL-5, preventing its interaction with eosinophils; in contrast, benralizumab binds to the IL-5 receptor (IL-5R), …

This article reviews the role of eosinophils in the pathogenesis of bronchial asthma and discusses the potential advantageous biologic effects of benralizumab in comparison with other …

Dec 22, 2010 · The IL-5 receptor (IL-5R) is a high-affinity receptor expressed on eosinophils, basophils, and mast cells and occurs as a heterodimer of IL-5Rα with the β subunit common to …