Interleukin 27 - Wikipedia
Interleukin 27 (IL-27) is a member of the IL-12 cytokine family. It is a heterodimeric cytokine that is encoded by two distinct genes, Epstein-Barr virus-induced gene 3 (EBI3) and IL-27p28.
IL-27 elicits a cytotoxic CD8 - Nature
Feb 5, 2025 · Our data demonstrate that endogenous IL-27 is essential for anti-tumour immunity and that IL-27 receptor agonism can safely improve anti-tumour T cell responses alone or in …
Regulation and Immune Function of IL-27 - PubMed
IL-27 is a pleiotropic cytokine that has diverse immune regulatory activities under both physiological and pathological conditions. IL-27 enhances the functions of Th1 and CD8 + T …
IL27: Its Roles in the Induction and Inhibition of Inflammation
IL27 is the newest member of the IL6/IL12 family. It consists of Epstein-Barr virus-induced gene 3 (EBI3) and p28 subunits and signals through the IL27 receptor complex formed by WSX-1 and …
IL-27-induced modulation of autoimmunity and its therapeutic …
Interleukin-27 (IL-27) is a new member of the IL-12 family. It is produced by activated antigen-presenting cells and plays an important role in the regulation of CD4+ T cell differentiation and …
The immunobiology of interleukin-27 - PubMed
Interleukin-27 (IL-27) is a cytokine with strikingly diverse influences on the immune response. Although it was initially linked with the development of Th1 responses, it is now recognized as …
IL-27 elicits a cytotoxic CD8+ T cell program to enforce ... - PubMed
Our data demonstrate that endogenous IL-27 is essential for anti-tumour immunity and that IL-27 receptor agonism can safely improve anti-tumour T cell responses alone or in combination …
Fifteen years of interleukin-27- discovery, advances and translation
Dec 12, 2012 · Interleukin-27 (IL-27) is a heterodimeric cytokine composed of the Epstein-Barr virus-induced gene 3 (EBi3) and IL-27p28, which engages a receptor composed of gp130 and …
Interleukin-27: Balancing Protective and Pathological Immunity
Dec 14, 2012 · Here we provide an overview of the immunobiology of IL-27 and review advances in understanding the functions of individual IL-27 and IL-27 receptor subunits and the role of IL …
IL-27 signalling promotes adipocyte thermogenesis and energy ...
Nov 24, 2021 · Here we define a critical role of IL-27–IL-27Rα signalling in improving thermogenesis, protecting against diet-induced obesity and ameliorating insulin resistance.