Interleukin-23 (IL-23) is a pro-inflammatory cytokine composed of two subunits, p19 and p40. The p40 subunit is shared with IL-12. IL-23 and IL-12 have different receptors and different effects.

Apr 29, 2024 · IL-23 controls immune cells. Learn how IL-23 is the target of potential Johnson & Johnson medications that could treat psoriasis, IBD and rheumatoid arthritis.

IL-23 acts locally in tissues by activating IL-23R + cells. IL-23 is a coordinating cytokine in psoriasis, psoriatic arthritis and inflammatory bowel disease. IL-23 history. IL-23 was …

Recent studies have demonstrated the crucial role of IL-23 in the regulation of Th1 cell responses and its potential role in the CD pathogenesis. IL-23 belongs to the IL-12 family, it is composed …

Regulatory mechanism of IL-23 in autoimmune diseases. IL-23 is involved in immune mediation by activating signaling pathways such as JaK-STAT, PI3K/Akt and NF-κB, thereby promoting …

Interleukin (IL-)23 is a central cytokine controlling T H 17 development. • Overshooting IL-23 signaling contribute to autoimmune diseases. • IL-23 is a member of the IL-12-type cytokine …

Apr 15, 2024 · Interleukin (IL)-23, an IL-12 cytokine family member, is a hierarchically dominant regulatory cytokine in a cluster of immune-mediated inflammatory diseases (IMIDs), including …

Mar 20, 2024 · Nur S, Sparber F, Lemberg C, et al. IL-23 supports host defense against systemic Candida albicans infection by ensuring myeloid cell survival. PLoS Pathog …

Feb 22, 2021 · The central contribution of IL-23/IL-17 axis in both PsA and psoriasis is confirmed by the efficacy of biologics neutralizing IL-17 or IL-23/IL-12 as well as the effectiveness of TNF …

Mar 12, 2025 · IL-23 inhibitors have transformed treatment for conditions like psoriasis and inflammatory bowel disease by selectively blocking key inflammatory signals. These inhibitors …