5 days ago · IKKα Antibody detects endogenous levels of total IKKα protein. The antibody does not cross-react with IKKβ or IKKγ. The antigen sequence used to produce this antibody shares 100% sequence homology with the species listed here, but reactivity has not been tested or confirmed to work by CST.

5 days ago · Monoclonal antibody is produced by immunizing animals with a synthetic phosphopeptide corresponding to residues surrounding Ser176/180 of human IKKα. The NF-κB/Rel transcription factors are present in the cytosol in an inactive state, complexed with the inhibitory IκB proteins (1-3).

5 days ago · Phospho-IKKα/β (Ser176/180) Antibody II detects endogenous levels of IKKα and IKKβ only when phosphorylated at Ser176 and Ser180 or Ser177 and Ser181, respectively. Human, Mouse, Rat, Monkey. Polyclonal antibodies are produced by immunizing animals with a phosphopeptide corresponding to a region surrounding Ser177/181 of IKKβ.

IKKa (IkB Kinase alpha subunit) – The IkB Kinase (IKK) complex is the key enzyme involved in the activation and translocation of NFkB (NFkB p50 & NFkB p65). The IKK complex is composed of two catalytic subunits (IKKa and IKKb) and a regulatory subunit (IKKg).

Proteintech's Rabbit Recombinant IKKA antibody is validated in IF/ICC, FC (Intra), ELISA and shows reactivity with human samples.

IKKα (3G12) Mouse mAb recognizes endogenous levels of total IKKα protein. Human, Monkey. Monoclonal antibody is produced by immunizing animals with a recombinant protein specific to a carboxy-terminal fragment of human IKKα protein.

Oct 25, 2012 · Espinosa and colleagues now identify a 45 kDa active nuclear isoform of IKKa (p45-IKKa) that associates with nonactive IKKa and NEMO to inhibit SMRT corepressor activity. Proteolytic cleavage of IKKa into p45-IKKa is required in order to sustain tumor growth in vivo.

Using cells from mice that are genetically deficient in IKKb or IKKa, or using a kinase inactive mutant of IKKb, it has been proposed that IKKb is critical for TNF-induced IkB phosphorylation/degradation through the canonical pathway while IKKa has been shown to be involved in the non-canonical pathway for NF-kB activation.

IKKα Kinase Regulates the DNA Damage Response and Drives Chemo-resistance in Cancer. Phosphorylated IKKα (p45) is a nuclear active form of the IKKα kinase that is induced by the MAP kinases BRAF and TAK1 and promotes tumor growth independent of canonical NF-κB signaling.

Mar 30, 2025 · IkappaB Kinase (IKK) is an enzyme complex that forms part of the NF-kappaB signaling pathway. The IKK complex is comprised of three subunits (IKKalpha (IKK1), IKKbeta (IKK2) and IKKgamma (NEMO)), the alpha- and beta-subunits are catalytically active whereas the gamma-subunit has a regulatory function. ...