This gene is a member of the Insulin-like growth factor-binding protein (IGFBP) family and encodes a protein with an IGFBP domain and a type-I thyroglobulin domain. The protein binds both insulin-like growth factors (IGFs) I and II and circulates in the plasma.

Mar 26, 2025 · Elevated insulin-like growth factor binding protein-1 (IGFBP-1) in men with metastatic prostate cancer starting androgen deprivation therapy (ADT) is associated with shorter time to castration resistance and overall survival. Sharma J, et al. Prostate, 2014 Feb. PMID 24132762. What's a GeneRIF?

In particular, IGFBP-1 is known to be an important regulator of IGF activity and mainly regulates metabolism in mammals. In this review, we focus on recent progress in elucidating the transcriptional regulation of IGFBP-1 among IGFBP isoforms. Keywords: IGFBP-1, Metabolic disease, Transcription, IGF.

Mar 30, 2025 · IGFBP1 (Insulin Like Growth Factor Binding Protein 1) is a Protein Coding gene. Diseases associated with IGFBP1 include Ovarian Disease and Insulin-Like Growth Factor I. Among its related pathways are Gene expression (Transcription) and Cellular responses to …

IGF-1 binds to IGFBP-3 in a 1:1 molar ratio. IGF-BP also binds to IGF-1 inside the liver, allowing growth hormone to continuously act upon the liver to produce more IGF-1. IGF binding proteins (IGFBPs) are proteins of 24 to 45 kDa.

In this review, we provided an overview of IGFBP-1 in normal physiology, and its aberrantly expression and the underlying molecular mechanisms in a range of common tumors, as well as discussed the potential clinical implications of IGFBP-1 …

IGFBP1 is inversely regulated by insulin (i.e., insulin down-regulates IGFBP1) and acts as a circulating inhibitor of IGF action by complexing IGFs. IGF-1 acts through its own receptor (the type 1 IGF receptor), which is structurally related to the insulin receptor and expressed widely.

Nov 2, 2024 · Elevated insulin-like growth factor binding protein-1 (IGFBP-1) in men with metastatic prostate cancer starting androgen deprivation therapy (ADT) is associated with shorter time to castration resistance and overall survival.

The level of insulin-like growth factor-binding protein 1 (IGFBP1), a liver-produced serum protein that regulates insulin-like growth factor-I bioactivity, glucose homeostasis, and tissue regeneration, increases during inflammation.

IGFBP-1 has been shown to inhibit somatic linear growth, weight gain, tissue growth, and glucose metabolism. Moreover, IGFBP-1 appears to be a primary determinant of free IGF-I levels in serum.