Here, we report that another immunoreceptor tyrosine-based inhibitory motif (ITIM)-containing receptor, platelet endothelial adhesion molecule-1 (PECAM1 / CD31), regulates FcγR function, and is itself regulated by FcγR activation.

CD31, or platelet endothelial cell adhesion molecule-1 (PECAM-1) is a member of the Ig gene superfamily expressed at high density at the lateral borders of endothelial cells (ECs) and at a lower density on the surface of hematopoietic cells including T lymphocytes (1).

Dec 15, 2019 · FcγR-mediated phagocytosis is regulated by the concerted actions of activating FcγR and inhibitory receptors, such as FcγRIIb and SIRPα. In this study, we report that another ITIM-containing receptor, PECAM1/CD31, regulates FcγR function and is …

Jun 1, 2013 · As a member of the immunoglobulin (Ig) gene superfamily, CD31 comprises six extracellular Ig folds; it has a molecular mass of 130 kDa and is differentially glycosylated, involving N -linked and O -linked glycosylation sites (Newton et al., 1999).

Jan 15, 1992 · CD31, as defined by a newly developed mAb termed anti-1F11, can divide activated as well as resting CD4 cells into distinct functional subpopulations, based on its surface expression. Among CD4 cells freshly isolated from peripheral blood, anti-1F11 preferentially reacts with the CD45RA+ subset.

May 1, 2019 · Abstract. Monocytes and macrophages express Fc-gamma Receptors (FcγR) that engage IgG immune complexes such as antibody-opsonized pathogens or cancer cells

In immunohistochemistry (IHC), CD31 is primarily used to demonstrate the presence of endothelial cells (Figure 2), to measure vessel density or to quantify (neo-)angiogenesis. Increasing evidence is showing that angiogenesis and inflammation are linked and play a cooperative role in various inflammatory diseases (reviewed in Jeong et al., 2020).

Jun 27, 2016 · We demonstrate that the CD20low/-CD138+CD31+ BM population was highly enriched for antibody-secreting cells with IgG being the predominant isotype (60%), followed by IgA (33%) and IgM (7%).

Dec 15, 2019 · CD31 is a member of the Ig gene superfamily that contains six extracellular domains, an intermembrane domain, and a cytoplasmic tail that bears two ITIMs capable of binding various molecules, including SHP1 and -2, SH2 domain containing inositol phosphatase 2, PI3K, and phospholipase C-γ1 (9, 10).

Oct 26, 2010 · We show that loss of CD31 interactions leads to enhanced primary clonal expansion, increased killing capacity, and diminished regulatory functions by T cells. Immunomodulation by CD31 signals correlates with a partial inhibition of proximal T-cell receptor (TCR) signaling, specifically Zap-70 phosphorylation.