Mar 30, 2025 · IFNGR2 (Interferon Gamma Receptor 2) is a Protein Coding gene. Diseases associated with IFNGR2 include Immunodeficiency 28 and Autosomal Dominant Mendelian Susceptibility To Mycobacterial Diseases Due To Partial Ifngammar2 Deficiency.

This gene (IFNGR2) encodes the non-ligand-binding beta chain of the gamma interferon receptor. Human interferon-gamma receptor is a multimer of two IFN-γR1 chains (encoded by IFNGR1) and two IFN-γR2 chains.

Jan 4, 2025 · Gene target information for IFNGR2 - interferon gamma receptor 2 (human). Find diseases associated with this biological target and compounds tested against it in bioassay experiments.

The interferon-gamma receptor (IFNGR) protein complex is the heterodimer of two chains: IFNGR1 and IFNGR2. It binds interferon-γ, the sole member of interferon type II.

This gene (IFNGR2) encodes the non-ligand-binding beta chain of the gamma interferon receptor. Human interferon-gamma receptor is a heterodimer of IFNGR1 and IFNGR2. Defects in IFNGR2 are a cause of mendelian susceptibility to mycobacterial disease (MSMD), also known as familial disseminated atypical mycobacterial infection.

Official gene symbol, which is typically a short form of the gene name, according to HGNC. Assigned HPA protein class (es) for the encoded protein (s). Number of protein-coding transcripts from the gene as defined by Ensembl.

Aug 12, 2021 · In this review, we summarize recent advances in the epigenetic, genetic, and functional integrity of the IFNγ signaling pathway in the colorectal cancer microenvironment and its immunological...

Oct 5, 2021 · Binding of interferon-γ (IFNγ) to the receptor subunit IFNGR1 leads to engagement of IFNGR2, which activates Janus kinase 1 (JAK1) and JAK2 to undergo autophosphorylation, and to phosphorylate...

Two clones of Ifngr2 KO RAW264.7 cells showed completely inhibited phosphorylation of JAK/STAT molecules upon IFN-γ stimulation (Figure S2 F), suggesting the phosphorylation of the molecules of JAK/STAT signaling is specifically triggered by IFN-γ binding with IFN-γR.

Feb 14, 2025 · Interferon-γ receptor deficiency (IFNGRD) is the most common cause of NSMD and has been associated with mutations in the gene IFNGR1 or IFNGR2. Depending on the exact mutation, disease severity can range from a mild form, which is easily treatable with prophylactic antibiotics and interferon-γ therapy, to a severe form, for which stem-cell ...