DGAT1 and DGAT2 Inhibitors for Metabolic Dysfunction …
Aug 21, 2024 · Inhibiting diacylglycerol acetyltransferase (DGAT1, DGAT2) enzymes (iDGAT1, iDGAT2), involved in triglyceride (TG) synthesis, improves hepatic steatosis in metabolic …
Cell cycle arrest induces lipid droplet formation and confers ...
Jan 2, 2024 · Mechanistically, cell cycle arrest induces diacylglycerol acyltransferase (DGAT)–dependent lipid droplet formation to sequester excessive polyunsaturated fatty acids …
Lipid droplet‐dependent fatty acid metabolism controls the …
To monitor the anti‐tumor effect of DGAT inhibitors (iDGAT) in vivo, CT26 tumor‐bearing mice were treated with vehicle or iDGAT starting at day 6 after tumor cell inoculation. As expected, …
DGAT1 and DGAT2 Inhibitors for Metabolic Dysfunction ... - PubMed
Aug 21, 2024 · Markers of hepatocellular damage were slightly decreased after single iDGAT exposure. Conversely, iDGAT1/2 counteracted ER/oxidative stress and inflammation and …
DGAT1-dependent lipid droplet biogenesis protects mitochondrial ...
The ER-resident diacylglycerol acyltransferase 1 (DGAT1) selectively channels autophagy-liberated FAs into new, clustered LDs that are in close proximity to mitochondria and are …
Metabolic reprogramming and lipid droplets are involved in Zika …
Mar 8, 2023 · Treatment with DGAT-1 inhibitor (A922500, iDGAT) reduces viral loads in the brain during acute infection, increases survival, and inhibits weight loss in ZIKV-infected mice. A …
Lipid droplet: A functionally active organelle in monocyte to ...
Oct 1, 2021 · This data clearly showed that LDs play a major role in sustaining the functional activity of differentiated macrophages beyond day 5 post-stimulation. Similarly, if we treated …
ers of hepatocellular damage were slightly decreased after single iDGAT exposure. Conversely, iDGAT1/2 counteracted ER/oxidative stress and inflammation and enhanced mitochondrial Tri …
Targeting lipid peroxidation-associated ferroptosis suppresses …
Sep 10, 2024 · Ferroptosis is halted through the mechanism of cell cycle arrest, which involves the deposition of intracellular lipids mediated by diacylglycerol acyltransferase (DGAT). …
Prevention of lipid droplet accumulation by DGAT1 inhibition ...
Dampening synthesis of hepatic LDs by inhibiting DGAT1 decreases inflammation, reduces lipid peroxidation, and improves liver function.