Lidocaine inhibits influenza a virus replication by up-regulating …
Feb 1, 2023 · Upon viral infection, lidocaine activates the intracellular TBK1-IRF7 and JNK-AP1(c-Jun) axes, resulting in phosphorylation and nuclear translocation of IRF7 and phosphorylation …
IRF-7 is the master regulator of type-I interferon-dependent
Mar 30, 2005 · Using mice deficient in the Irf7 gene (Irf7-/-mice), we show that the transcription factor IRF-7 is essential for the induction of IFN-α/β genes via the virus-activated, MyD88 …
Chemotherapeutic DNA-damaging drugs activate interferon …
Mar 1, 2000 · Furthermore, IRF7 was activated by the c-Jun NH2-terminal kinase (JNK) in response to DNA-damaging agents. Activation of JNK by mitogen-activated protein kinase …
Transcriptional repression of IRF7 by MYC is critical for type I ...
IRF7 is a critical regulator of type I IFN production when pathogens are detected by Toll-like receptor (TLR) 7/9 in pDC. However, hyperactivation of pDC can cause life-threatening …
Lidocaine inhibits influenza a virus replication by up ... - PubMed
Mechanistically, lidocaine upregulated IFNα4 by activating TANK-binding kinase 1 (TBK1)-IRF7 and JNK-AP1 signaling pathways. These findings indicate that lidocaine has an incredible …
NF-κB, JNK, and TLR Signaling Pathways in Hepatocarcinogenesis
Nov 28, 2010 · The findings implicating a pivotal contribution of JNK in HCC development suggest the use of a JNK inhibitor for treating HCC. The most commonly used JNK inhibitor is …
Deletion of Irf3 and Irf7 Genes in Mice Results in Altered …
Our results indicate that upregulation of the Irf3- and Irf7-independent pathways, namely the JNK pathway, and the resulting higher infiltration of granulocytes may be an important driver of a …
IRF7 activation by Epstein–Barr virus latent membrane protein 1 ...
Nov 11, 2008 · Epstein–Barr virus (EBV) latent infection membrane protein 1 (LMP1), a constitutively aggregated and activated pseudoreceptor, activates IFN regulatory factor 7 …
Repolarizing heterogeneous leukemia-associated macrophages …
Targeting IRF7-SAPK/JNK pathway, which accounted for different activation of LAMs, to induce M1 characteristics contributed to prolonged survival in leukemia mice. Our findings provide …
IRF7 contribute to M1-like phenotypes through the activation of ...
Yang et al. revealed that the acquisition of M1 characteristics in leukemiaassociated macrophages (LAMs) through activation of the IRF7-SAPK/JNK pathway was associated with prolonged …