Nov 7, 2023 · IRF4-C99R thoroughly modifies IRF4 function by blocking IRF4-dependent plasma cell induction, and up-regulates disease-specific genes in a non-canonical Activator Protein-1 …

Mar 27, 2017 · Variable strengths of signaling via the T cell antigen receptor (TCR) can produce divergent outcomes, but the mechanism of this remains obscure. The abundance of the …

IRF4-C99R fundamentally alters IRF4 DNA-binding, with loss-of-binding to canonical IRF motifs and neomorphic gain-of-binding to canonical and non-canonical IRF CEs. IRF4-C99R …

IRF4 binds DNA weakly due to a C-terminal auto-inhibitory domain, but cooperative binding with factors such as PU.1 or SPIB in B cells increases binding affinity 3, allowing IRF4 to regulate …

Sep 2, 2010 · In this study, we show that IRF4 is upregulated in TCR-signaled thymocytes and is predominantly expressed in CD4 single-positive (SP), but not in CD8 SP, cells. T-cell-specific …

We show that enhancers controlling BATF-dependent TCR-inducible genes respond to different levels of BATF/IRF4. Genes highly sensitive to low BATF levels can be compensated by …

Mar 18, 2025 · To understand the functional implications of the BCL7A-IRF4 complex, we therefore performed a competitive electrophoretic mobility shift assay (EMSA) and observed …

Dec 15, 2018 · A reporter assay and an EMSA revealed that the Aldh1a2 promoter was synergistically transactivated by a heterodimer composed with PU.1 and IRF4 via the EICE …

Jan 20, 2023 · Interferon regulatory factor 4 (IRF4) is a transcription factor (TF) and key regulator of immune cell development and function. We report a recurrent heterozygous mutation in …

IRF3 and IRF4 were the only isoforms with a significant effect on lipid accumulation (Fig. 4A) and terminal gene expression (Fig. 4B). All other IRF isoforms repressed at least one (non …