Among myeloid cells, IRF4 expression has been identified in dendritic cells (DCs) and macrophages. [8][9] The transcription factors IRF4 and IRF8 work in concert to achieve DC differentiation. [8][9] IRF4 expression is responsible for inducing development of CD4+ DCs, while IRF8 expression is necessary for the development of CD8+ DCs. [9] .

IRF4 regulates the migration of DCs in the skin as well as the differentiation of specialized DC subsets, which can promote either T H 17 or T H 2 responses [22 – 26].

IRF4 is a key regulator of several steps of lymphoid, myeloid and dendritic cell (DC) differentiation. Particular attention has recently been dedicated to the role of IRF4 in B-cell differentiation and function. 72 The functions of IRF4 in oncogenesis and tumor progression, in particular in relationship to hematopoietic malignancies, has been ...

Nov 6, 2015 · Although autoimmunity in DKO mice is accompanied by dysregulated IRF4 activity in both T and B cells, SWAP-70 is also known to regulate multiple aspects of DC biology leading us to directly evaluate DC development and function in these mice.

Here we investigated whether the development and migration of skin resident DC were regulated by interferon regulatory factor 4 (IRF4), a transcription factor that is required for the development of CD11b + splenic DC.

Dec 12, 2012 · Our data revealed heterogeneity in the mouse CD11b + DC compartment and identifed mucosal tissues IRF4-expressing DCs specialized in instructing IL-17 responses in both mouse and human.

Nov 9, 2016 · IRF4 is a hematopoietic-specific transcription factor critical for lymphoid and myeloid lineage development and function, and its expression is thus restricted to immune cells such as T cells, B cells, macrophages, and dendritic cells (DCs). Herein, we summarize the specific roles of IRF4 in immune cell development.

Feb 2, 2016 · IRF4-expressing DCs are important for the DC-driven polarization of T H 17 responses in the intestine and lung ( 6, 7 ), for the induction of T H 2 responses in lung allergy and skin parasite models ( 8 – 10) and for attenuation of T H 1 responses ( 11 ).

May 23, 2013 · CD103 + CD11b + dendritic cells (DCs) represent the major migratory DC population within the small intestinal lamina propria (SI-LP), but their in vivo function remains unclear. Here we demonstrate that intestinal CD103 + CD11b + DC survival was dependent on interferon regulatory factor 4 (IRF4).

Nov 6, 2020 · All pathogens are taken up by a population of IRF4+ dermal migratory dendritic cells (migDC2) that similarly upregulate surface co-stimulatory molecules but express pathogen-specific...