Nov 13, 2020 · Here, we unexpectedly found that the IRF3 deficient mice are hyper-susceptible to the development of intestinal tumor in AOM/DSS and Apc min/+ models. Genetic ablation of IRF3 profoundly...

Recently, the author established the relationship between cytosolic IRF3 and Wnt/β-catenin signalling via AOM/DSS-induced chronic colonic inflammation mice models, demonstrating that IRF3 is a tumour suppressor, inhibiting Wnt signalling, instead of functioning as a …

Interferon regulatory factor 3 (IRF3) serves as the key signal mediator and transcription factor for the induction of IFN-I. Upon pathogen infection, IRF3 undergoes serial processes of phosphorylation followed by homodimer formation and nuclear translocation to …

Here, we found an intriguing function of cytosolic IRF3 in resting state to inhibit colorectal tumorigenesis via the prevention of Wnt/-catenin signaling. IRF3 binds to the armadillo repeats...

Apr 4, 2017 · We found that this network intersects the IRF3 terminal signaling pathway and that its repression results in the induction of the IRF3-mediated antiviral response when cells are exposed to pathogen-associated molecular patterns (PAMPs) (e.g., viral double-stranded RNA).

Oct 9, 2024 · Interferon Regulatory Factors (IRFs), a family of transcription factors, profoundly influence the immune system, impacting both physiological and pathological processes.

Nov 24, 2020 · Therefore, our study identifies IRF3 as a negative regulator of the Wnt/β-catenin pathway and a potential prognosis marker for Wnt-related tumorigenesis, and describes an intriguing link between gut microbiota and CRC via the IRF3-β-catenin axis.

IRF3 was able to exert a suppressive effect on development of colon cancer and epithelial cell proliferation by blocking Wnt signaling [31]. In the study by Yuan Si and colleagues, reduced ...

Mechanistically, we found that β‐catenin interacted with IRF3 and blocked its nuclear translocation. Our study reveals an unprecedented role of β‐catenin in enabling innate immune evasion in CRC. Keywords: β‐catenin, colorectal cancer, innate immunity, IRF3, RIG‐I‐like receptor (RLR)‐mediated IFN‐β signalling pathway. 1. INTRODUCTION.

Nov 13, 2020 · Therefore, our study identifies IRF3 as a negative regulator of the Wnt/β-catenin pathway and a potential prognosis marker for Wnt-related tumorigenesis, and describes an intriguing link between gut microbiota and CRC via the IRF3-β-catenin axis.