Jan 24, 2020 · Enrichment analysis and the machine learning method uncovered the features that favour IRF3 or IRF9 dominancy (e.g. a tripartite form of ISRE and motifs for NF-κB for IRF3, and the GAS motif and certain ISRE variants for IRF9).

Jul 25, 2022 · By developing a genetic code expansion orthogonal system, we demonstrated the presence of an acetyl moiety at specific IRF3/IRF7 DBD site/s abolish IRF3/IRF7 LLPS and IFN-I induction. SIRT1...

irf-3 磷酸化和随后的二聚化会诱导 irf-3 核转位，irf-3 随后结合干扰素刺激应答元件 (isre)，从而导致 i 型干扰素基因表达。 胞质双链 DNA 检测也通过多个入口流入 TBK1-IRF-3 信号转导轴。

Sep 1, 2006 · Following ligation of Toll-like receptor 4 (TLR4), the IRF3-mediated activation of ISRE-containing genes, such as those encoding CXCL10 (CXC-chemokine ligand 10) and IFIT1 (IFN-induced...

Dec 4, 2019 · Enrichment analysis and the machine learning method uncovered the features that favour IRF3 or IRF9 dominancy (e.g. a tripartite form of ISRE and motifs for NF-κB for IRF3, and the GAS motif and certain ISRE variants for IRF9).

We show that IRF3 and IRF7 bind to many interferon-stimulated response element (ISRE)-type sites in the virus-response elements (VREs) of IFN promoters. However, strikingly, IRF5 does not bind the VREs, suggesting evolutionary selection against IRF5 homodimer binding.

May 31, 2017 · To identify such compounds, we developed a high-throughput screening assay based on HEK-293 cells expressing luciferase under the control of Interferon-Stimulated Response Elements (ISRE).

Ubiquitously expressed interferon regulatory factor 3 (IRF-3) is directly activated after virus infection and functions as a key activator of the immediate-early alpha/beta interferon (IFN) genes, as well as the RANTES chemokine gene.

Jun 1, 2022 · In recent years, IRF3 has been considered a principal early regulator of type I IFNs (TI-IFNs) directly downstream of intracellular virus sensing. Despite decades of research on IRF-activating pathways, many questions remain on the regulation of IRF3 activation.

Feb 28, 2008 · In this study, we report that in non‐infected cells IRF3 is post‐translationally modified by S ‐glutathionylation. Upon viral‐infection, it undergoes a deglutathionylation step that is controlled by the cytoplasmic enzyme glutaredoxin‐1 (GRX‐1).