Sep 1, 2006 · By contrast, IRF3 has an essential role in the TRIF-dependent pathway of type I IFN gene induction by TLR4. IRFs interact with other transcription factors, such as NF-κB, and …

Oct 9, 2024 · In mammals, nine IRF members have been reported, 10 designated as IRF1 (also known as MAR), IRF2, IRF3, IRF4 (known alternatively as LSIRF/ICSAT/ PIP), IRF5, IRF6, …

IRF3 was originally discovered as a homolog of IRF1 and IRF2. IRF3 has been further characterized and shown to contain several functional domains including a nuclear export …

May 20, 2024 · IRF3 promotes weight gain, primarily by inhibiting adipose thermogenesis, and also induces inflammation and insulin resistance using both weight-dependent and weight …

Feb 1, 2015 · The expression of all nine mammalian IRF mRNAs is regulated during adipogenesis, and IRF1, IRF3, and IRF4 exhibit anti-adipogenic properties in cultured …

IRF4 deficient mice are characterized by normal distribution of B and T cells in earlier development with progressing lymphadenopathy throughout differentiation stages. IRF4 has …

IRF1 and IRF2 share another IRF association domain (IAD2), which is structurally distinct from IAD1. IRF3 and IRF7 have multiple sites that—upon viral infection—are substrates for …

Nov 20, 2018 · More recent findings suggest that IRF4 polymorphisms are associated with high risk of rheumatoid arthritis (RA) (17, 42, 43) and systemic sclerosis (17, 43). Mutations in IRF6 …

Interferon regulatory factor 4 (IRF4) also known as MUM1 is a protein that in humans is encoded by the IRF4 gene. [5][6][7] IRF4 functions as a key regulatory transcription factor in the …

Some IFNs like IRF2 and IRF4 regulate the activation of IFNs and pro-inflammatory cytokines through inhibition. IRF2 contains a repressor region that downregulates expression of type I …