Interferon regulatory factor 1 is a protein that in humans is encoded by the IRF1 gene. [4][5] Interferon regulatory factor 1 was the first member of the interferon regulatory transcription factor (IRF) family identified.

Jan 21, 2021 · The eponymous member of the interferon regulatory factor (IRF) family, IRF1, was originally identified as a nuclear factor that binds and activates the promoters of type I interferon genes.

Mar 30, 2025 · IRF1 (Interferon Regulatory Factor 1) is a Protein Coding gene. Diseases associated with IRF1 include Immunodeficiency 117 and Gastric Cancer. Among its related pathways are Bacterial infections in CF airways and Overview of …

Mar 1, 2025 · IRF1 collaborates with ELF1, ETV6, RUNX2, and MEF2D to form a core transcriptional regulatory circuit that promotes AML progression. Furthermore, we demonstrated that IRF1 directly regulates the expression of key genes involved in lipid metabolism, influencing the synthesis of diverse lipid molecules crucial for AML survival.

Oct 9, 2024 · Interferon Regulatory Factors (IRFs), a family of transcription factors, profoundly influence the immune system, impacting both physiological and pathological processes.

Jan 21, 2021 · The eponymous member of the interferon regulatory factor (IRF) family, IRF1, was originally identified as a nuclear factor that binds and activates the promoters of type I interferon genes.

Sep 1, 2006 · Four IRFs — IRF1, IRF3, IRF5 and IRF7 — have been implicated as positive regulators of the transcription of type I IFN genes 4, 14. IRF1 was the first IRF-family member that was discovered to ...

Jul 8, 2019 · Here, we show that TNF regulates the expression of the transcription factor interferon regulatory factor 1 (IRF1) in human FLSs as well as in a TNF transgenic arthritis mouse model.

Oct 27, 2023 · We investigated the role of interferon regulatory factor 1 (IRF1), a transcription factor that is affected by multiple inflammatory stimuli, in HSC regulation. Our findings demonstrate that the loss of IRF1 from mouse HSCs significantly impairs self-renewal, increases stress-induced proliferation, and confers resistance to apoptosis.

Feb 2, 2023 · IRF1 encodes interferon regulatory factor 1 protein (IRF1), a transcription factor induced by IFN-γ, the deficiency of which in mice underlies susceptibility to various pathogens, including mycobacteria 43,44,45,46,47,48,49,50,51,52,53,54,55,56,57 (Table S2).