Jul 10, 2019 · In this study, we discovered that the Wnt/β-catenin signaling destabilizes IRF1 through the ubiquitination-proteasome pathway, and that reduced expression of IRF1 is …

IRF1 is a transcription factor well known for its role in IFN signaling. Although IRF1 was initially identified for its involvement in inflammatory processes, there is now evidence that it provides …

Jul 9, 2013 · Functional interpretation analysis showed mTOR and Wnt/β-cathenin as the top downregulated pathways in the cell lines with low inducible IRF-1 activation, suggesting that a …

Feb 10, 2024 · IRF1 is a transcription factor well known for its role in IFN signaling. Although IRF1 was initially identified for its involvement in inflammatory processes, there is now evidence that …

Jun 11, 2019 · Further rescue assays confirmed the crucial roles of miR-18a and miR-19a in the IRF-1-mediated inhibition of Wnt/β-catenin signalling. We also demonstrated that IRF-1 binds …

Jun 27, 2013 · Functional interpretation analysis showed mTOR and Wnt/ β -cathenin as the top downregulated pathways in the cell lines with low inducible IRF-1 activation, suggesting that a …

Nov 2, 2020 · Autophagy is an important factor in liver ischemia-reperfusion injury. In the current study we investigate the function of interferon regulatory factor-1 (IRF1) in regulating …

Nov 7, 2013 · Functional interpretation analysis showed mTOR and Wnt/β-cathenin as the top upregulated pathways in the cell lines with low inducible IRF-1 activation, suggesting that a …

Mar 15, 2025 · Western blot, transmission electron microscope, IF, and ELISA assays were used to explore the effects of IRF1, Nuclear receptor coactivator 1 (NCOA1), and Wnt/β-catenin …

IRF-1 regulates expression of target genes by binding to an interferon stimulated response element (ISRE) in their promoters. The IRF-1 protein binds to the ISRE via an N-terminal helix …