In this study, we showed that knockout of interferon regulatory factor 1 (IRF-1) in mice strongly attenuated the generation of NETs and reactive oxygen species (ROS) production in neutrophils from bronchoalveolar lavage fluid and alleviated LPS …

Our data suggest that IRF‐1 is inessential for differentiation but upregulates p47phox expression for mature‐cell ROS production. Keywords: differentiation, HL‐60 cells, inducible oxidative metabolism, interferon regulatory factor‐1 (IRF‐1), retinoic acid. 1. INTRODUCTION.

Jun 15, 2007 · Collectively, these findings demonstrate that TNF-alpha/IFN-gamma synergistically potentiates iNOS/NO induction, ROS production, and loss of DeltaPsim via STAT1 overexpression, playing an important role in promoting apoptosis and …

CONCLUSIONS: IRF-1 engages in LPS induced ROS production and mitochondrial damage in macrophages. CLINICAL IMPLICATIONS: As ROS production and mitochondrial damage play a important role in sepsis, our research may prove a new clue for the therapy of sepsis.

Dec 6, 2024 · Silencing IRF-1 Expression Enhanced ROS Accumulation and Intrinsic Apoptosis of HAEC caused by oxLDL Stimulation. Exposure of HAEC to oxLDL is an established in vitro model to study metabolic stress that promotes athero-inflammation.

In vivo, peritoneal macrophages obtained from IRF-1 KO mice demonstrate significantly decreased ROS production, mitochondrial depolarization and mitochondrial structure damage. CONCLUSIONS: IRF-1 engages in LPS induced ROS production and mitochondrial damage in …

ROS affects Irf-1-dependent cyclin E/CDK2 expression and cell cycle regulation under high glucose conditions

Jun 15, 2007 · This study also demonstrates that STAT1/IRF-1 plays a critical role in inducing iNOS/NO as well as ROS production and loss of ΔΨm induced by TNF-α/IFN-γ. Our results provide a rationale for new clinical perspectives on the development of …

Feb 1, 2019 · In this study, we showed that knockout of interferon regulatory factor 1 (IRF-1) in mice strongly attenuated the generation of NETs and reactive oxygen species (ROS) production in...

In vitro, LPS was found to promote IRF-1 activation, reactive oxygen species (ROS) production, adenosine triphosphate (ATP) depletion, superoxide dismutase (SOD) consumption, malondialdehyde (MDA) accumulation and mitochondrial depolarization in macrophages in a time- and dose-dependent manner.