Jan 15, 2021 · In the absence of perforin, we show that GrB enzymatic activity still induces substoichiometric activation of caspases, which through nonlethal DNA damage response signals then leads to activity-associated phosphorylation of IFN regulatory factor-3.

It revealed GzmB-dependent yet Perforin-independent DNA fragmentation in intestinal epithelial cells, while GzmB can still concurrently engage Perforin-dependent pathways. This challenges the binary perception of GzmB delivery, emphasizing its nuanced interplay with both mechanisms.

Feb 24, 2023 · Using an IL-2 complex to activate GzmB expression in the non-immunogenic B16-F10 tumor model, we provide evidence to show that GzmB produced by Tregs is important for spontaneous metastasis to the lungs.

Oct 9, 2024 · This review explores the diverse functions of nine mammalian IRF members, each featuring conserved domains essential for interactions with other transcription factors and cofactors.

We found that TAMs represented the most abundant member of the MPS and expressed high IRF8, which was required for their proliferation, maturation, and presentation of cancer cell-associated antigens to CTLs.

Interferon regulatory factor 1 (IRF-1) is a tumor suppressor gene in cancer biology with anti-proliferative and pro-apoptotic effect on cancer cells, however mechanisms of IRF-1 regulating tumor microenvironment (TME) in hepatocellular carcinoma (HCC) remain only …

Jan 11, 2012 · Notably, the ability of Tregs to regulate lung inflammation during RSV infection critically depended on their ability to produce granzyme B (GzmB), a cytotoxic mediator normally associated with...

May 23, 2024 · This review underscores the multifaceted roles of GzmB, spanning immunological and pathological contexts, which call for further investigations to pave the way for innovative targeted therapies. Keywords: cytotoxic lymphocytes; granzyme B; immune response; inflammatory disorders; perforin.

Secreted I-IFN activated the JAK/STAT signaling pathway in CD8 + T cells, and promoted IFN-γ and GZMB secretion. Together, the study shows that tumor-derived exosomes promote I-IFN secretion via the circPIK3R3/miR-872-3p/IRF7 axis in macrophages and enhance the anti-tumor immune response of CD8 + T cells.

Mar 10, 2022 · Granzyme B (GzmB) is a potent cytotoxic molecule that is used by cytotoxic T lymphocytes and natural killer cells to kill targeted infected or cancerous cells. Since its discovery, there has been growing evidence showing more roles besides cell death such as tissue development and repair.