Idiopathic pulmonary fibrosis (IPF) is a fatal lung disease that is characterized by replacement of the normal lung anatomy with active remodeling and deposition of extracellular matrix (ECM) accompanied by a shift in lung cellular communities. The most common outcome of this debilitating disease is respiratory failure and subsequent death.

Jul 8, 2020 · We provide a single-cell atlas of idiopathic pulmonary fibrosis (IPF), a fatal interstitial lung disease, by profiling 312,928 cells from 32 IPF, 28 smoker and nonsmoker controls, and 18 chronic obstructive pulmonary disease (COPD) lungs.

Mar 27, 2025 · Rutgers Health researchers have discovered that networks of misplaced immune cells drive an aggressive lung disease, potentially opening a path to new treatments for a condition that kills 80% of patients within a decade. Idiopathic pulmonary fibrosis (IPF) scars lung tissue and makes breathing ...

Oct 20, 2017 · Idiopathic pulmonary fibrosis (IPF) is a chronic, progressive lung disease characterized by progressive lung scarring and the histological picture of usual interstitial pneumonia (UIP). It is...

Mar 16, 2025 · Idiopathic pulmonary fibrosis (IPF) is a chronic interstitial lung disease (ILD) characterized by scarring of lung tissue, which progressively impairs lung function, eventually leading to respiratory failure and death [].Epidemiological data indicate that the incidence of IPF ranges from 0.09 to 1.30 per 10,000 people, with prevalence between …

Aug 1, 2024 · We used single-cell RNA sequencing data to investigate the transcriptional profiles of immune cells in the lungs of 5 IPF patients and 3 subjects with non-fibrotic lungs. In an identifiable population of immune cells, we found increased percentage of CD8 + T cells in the T cell subpopulation in IPF.

May 30, 2024 · Possible immune cell responses in idiopathic pulmonary fibrosis (IPF), a chronic and deadly lung disease characterized by lung scarring, have been suggested for years. Yet, until now, detailed profiles of these cells have been lacking.

An important feature of epithelial cell remodeling in IPF is the expansion of distal basal cells, which can serve as stem/progenitor cells of the pseudostratified epithelium of the lung.

Idiopathic Pulmonary Fibrosis (IPF) is a progressive interstitial lung disease marked by increasing dyspnea and respiratory failure. The underlying mechanisms remain poorly understood, given the complexity of its pathogenesis. ... Studies have revealed that various cell types, including alveolar epithelial cells, fibroblasts, myofibroblasts ...

Jul 7, 2018 · IPF is a progressive fibrosing interstitial lung disease in which innate and adaptive inflammatory processes are activated. This review gives an up-to-date overview of new trials for IPF treatment and their interaction with the immune system.