Jan 3, 2023 · In vivo deletion of IL-1rn induces hematopoietic stem cell (HSC) differentiation into the myeloid lineage and hampers B cell development via transcriptional activation of myeloid...

In vivo deletion of IL-1rn induces hematopoietic stem cell (HSC) differentiation into the myeloid lineage and hampers B cell development via transcriptional activation of myeloid differentiation …

Jan 17, 2023 · Haematopoietic ageing is marked by a loss of regenerative capacity and skewed differentiation from haematopoietic stem cells (HSCs), leading to impaired blood production. …

Hu Z, Shao M, Chen Y, Zhou J, Qian J, Xu L, Ma H, Wang X, Xu Y, Lu D, Shen H. Allele 2 of the interleukin-1 receptor antagonist gene (IL1RN*2) is associated with a decreased risk of …

Jan 6, 2022 · To test whether HSC aging is driven by IL-1a/b, we evaluated HSCs from IL-1 receptor 1 (IL-1R1) knockout (KO) mice. Indeed, older HSCs from IL-1R1KO mice show …

Our data reveal that HSC differentiation is controlled by balanced IL-1 /IL-1rn levels under steady-state, and that loss of repression of. IL-1 signaling may underlie pre-leukemic lesion...

Mar 14, 2019 · We aimed to determine whether the modulation of IL-1β signaling with IL-1Ra impacts on liver fibrosis. Methods: We assessed the effects of IL-1β on human hepatic stellate …

Mar 1, 2020 · Consistent with previous results that IL1RN treatment in fibrotic mice significantly reduced the severity of liver fibrosis, 18 IL1RN significantly reduced fibrogenic responses and …

Apr 1, 2023 · IL1RA gene (IL1RN) carries polymorphisms in a variety of squamous cell carcinomas. IL1RA exhibits inhibitory effects on various squamous cell carcinomas. …

Jul 17, 2023 · Furthermore, knockdown of IL-1RA in HSC-3 cells reduced tumorsphere formation (Fig. 2 C), whereas overexpression of IL-1RA in OECM-1 cells increased tumorsphere …