The IL6 receptor is a protein complex consisting of an IL-6 receptor subunit (IL6R) and interleukin 6 signal transducer Glycoprotein 130. IL6R also denotes the human gene encoding this subunit.

Mar 30, 2025 · IL6R (Interleukin 6 Receptor) is a Protein Coding gene. Diseases associated with IL6R include Hyper-Ige Syndrome 5, Autosomal Recessive, With Recurrent Infections and Interleukin 6, Serum Level Of, Quantitative Trait Locus. Among its related pathways are TGF-Beta Pathway and MIF Mediated Glucocorticoid Regulation.

IL-6 induces intracellular signaling pathways after binding to its membrane-bound receptor (IL-6R), which is only expressed on hepatocytes and certain subpopulations of leukocytes (classic signaling). Transduction of the signal is mediated by the membrane-bound β …

IL-6 (orange) first binds to the IL-6 receptor (IL-6R) (red). The complex of IL-6 and IL-6R associates with glycoprotein 130 kDa (gp130) (blue), which dimerises and leads to intracellular signalling. It is important to note that IL-6 and IL-6R alone exhibit no measurable affinity to gp130.

Interleukin (IL-)6 is the major pro-inflammatory cytokine within the IL-6 family. IL-6 signals via glycoprotein 130 (gp130) and the membrane-bound or soluble IL-6 receptor (IL-6R), referred to as classic or trans-signaling, respectively.

Apr 23, 2020 · To mark the tenth anniversary of anti-IL-6 receptor therapy worldwide, we discuss the history of research into IL-6 biology and the development of therapies that target IL-6 signalling,...

IL-6R (trans-signaling) is a key regulator of reverse cholesterol transport in lipid-laden macrophages. Genetic variations of IL10 and IL6R genes in acute anterior uveitis in Han Chinese. Causal relationship of interleukin-6 and its receptor on …

IL-6 exerts its biological activities through two molecules: IL-6R (IL-6 receptor) and gp130. When IL-6 binds to mIL-6R (membrane-bound form of IL-6R), homodimerization of gp130 is induced and a high-affinity functional receptor complex of IL-6, IL-6R and gp130 is formed.

IL-6 works through an interaction with the complex peptide IL-6 receptor (IL-6R). IL-6 is built with four α-chain nanostructures, while two different chains, IL-6Rα (gp80) and gp130/IL6β (gp130), are included in IL-6R.

Feb 8, 2025 · Interleukin 6 receptor (IL-6R) was an independent prognostic factor in cervical cancer. Increased copy number of the interleukin-6 receptor gene is associated with adverse survival in multiple myeloma patients treated with autologous stem cell transplantation.