A newly developed STAT3 specific inhibitor (stattic) blocked LPS-mediated STAT3 tyrosine phosphorylation and led to inhibition of LPS-mediated IL-1beta and IL-6 production but not TNF-alpha production.

We found that inflammatory cytokines highly expressed in RA patients, such as IL-1β, tumor necrosis factor alpha and IL-6, activated STAT3 either directly or indirectly and in turn induced expression of IL-6 family cytokines, further activating STAT3 in murine osteoblastic and fibroblastic cells.

Feb 2, 2015 · Here we found that IL-1 was needed to fully override RA-mediated expression of the transcription factor Foxp3 and induce protective T H 17 cell responses.

Here, we show that IL-1β promotes STAT3 binding to key cis- elements that control IL-17 expression. Additionally, we demonstrate that the IL-1–induced NF-κB factor RelA directly regulates the Il17a/f loci in cooperation with STAT3.

We show that IL-1 induces LIF expression and downstream JAK/STAT activation to generate inflammatory CAFs, and demonstrate that TGF-β antagonizes this process by downregulating IL-1R1 expression and promoting differentiation into myofibroblasts.

Feb 1, 2022 · IL-1β promotes pro-angiogenic VEGF-A 165 a isoform transcription via activation and promoter binding of STAT3 and NF-κB, as demonstrated by gene-deletion, gain-of-function, inhibition, and chromatin immunoprecipitation assays.

Through induction of an NF-κB-dependent repression of SOCS3 expression, IL-1 increased the amplitude and duration of STAT3 phosphorylation induced by T H 17-polarizing cytokines, leading to an altered balance of STAT3–STAT5 binding to …

Dec 25, 2024 · Elevated cytokines IL-1β and IL-6 affect endothelial cell dysfunction through the STAT pathway after major abdominal surgery. The activation of STAT3 by IL-6 promotes endothelial cell proliferation, whereas STAT1 activation by IL-1β counteracts this effect, highlighting a critical regulatory balance in endothelial cell functionality following ...

IL-1beta release is partially inhibited in NOMID cells by caspase-1 inhibitors, and is blocked completely by inhibitors of cathepsin B. Cathepsin B inhibitors also prevent pyronecrosis. Similar to cathepsin, STAT3 inhibitors significantly abrogated cell …

May 1, 2009 · Interleukin 1 beta (IL-1β) is a potent pyrogen and a key regulatory cytokine that exerts its effect at low concentrations and is lethal in higher concentrations (Dinarello, 1998). IL-1β plays a pivotal role in the pathogenesis of several autoinflammatory diseases (Dinarello, 2002).