FcεRII has multiple functions as a membrane-bound or soluble receptor; it controls B cell growth and differentiation and blocks IgE-binding of eosinophils, monocytes, and basophils.

The fragment crystallizable region (Fc region) is the tail region of an antibody that interacts with cell surface receptors called Fc receptors and some proteins of the complement system. This …

Immunoglobulin Fc receptors (FcRs) are membrane molecules expressed by several hematopoietic cells that recognize the Fc region of several immunoglobulin (Ig) classes and …

Apr 24, 2023 · FcμR is the immunoglobulin M (IgM) antibody isotype-specific Fc receptor involved in the survival and activation of B cells. Here we reveal eight binding sites for the human FcμR …

Overview of human Fcγ receptors, including affinity for immunoglobulin (Ig) G and expression profile. ITAM = immunoreceptor tyrosine-based activation motif; NK = natural killer; ITIM = …

Jan 1, 1996 · Fc receptors are cell membrane molecules that specifically bind the Fc portion of an immunoglobulin heavy chain. These receptors have been defined on leukocytes for all Ig …

Since the description of the first mouse knockout for an IgG Fc receptor seven years ago, considerable progress has been made in defining the in vivo functions of these receptors in …

Jul 25, 2018 · The Fc was the first domain of the Ig structure to be solved by crystallography, but only after proteolysis, highlighting the flexibility of the molecule conferred by the Ig hinge region.

Recombinant immunoglobulin Fc domains for use as assay standards or controls. We offer a range of isotype- and species-specific Ig Fc domains.

Antibodies all have the same basic structure consisting of two heavy and two light chains forming two Fab arms containing identical domains at either end attached by a flexible hinge region to …