Jun 8, 2022 · Here, we assessed the impact of cytotoxic T cells on the local lymphatic vasculature and concomitant tumor dissemination during an antitumor response. Interferon-γ (IFN-γ) …

Jul 9, 2024 · For LC3 detection, MC38 cells cultured in six-well plates were treated with 1 μg/mL recombinant IFN-α or 100 ng/ml recombinant IFN-γ for 48 h with or without 50 μM chloroquine …

Dec 6, 2022 · By generating Tbk1-KO MC38 cells, where IFN production is lost without manipulating dsDNA or 2′3′-cGAMP levels, we evaluated the specific role of cancer cell …

To investigate the effects of type I IFN signaling in cancer cells, we prevented this signaling in 4 murine cancer cell lines: MC38 (colorectal carcinoma), B16F10 (melanoma), KPC (pancreatic …

Aug 8, 2019 · The binding of the IFN fusion proteins to murine PD-L1 was evaluated by FACS analysis against the murine PD-L1-expressing MC38 cell line. The anti-PD-L1-IFN-α retains …

To characterize the role of IRF1 in tumor cells, we generated Irf1 −/− clones of highly immunogenic (MC38) and less immunogenic (B16F10 and YUMM2.1) tumor cells and …

5 days ago · We identified 22 genes that are consistently upregulated in tumor-infiltrating T cells upon simultaneous expression of IFNα and IL-12 in both MC38 and AKTPF LMs, hereon …

Apr 7, 2025 · By combining IONPs with the STING agonist MSA- 2, the generation of ROS by IONPs and the subsequent activation of NF-κB are harnessed to boost IFN-I production, …

6 days ago · As presented in Fig. 5A-C, for adaptive immune response, the proportions of CD8 + T cells, IFN-γ + / CD8 + T cells, and Th1 cells (T-bet + / CD4 +) were evidently increased after …

Oct 7, 2021 · We show that interferon-γ (IFN-γ) reduced tumor progression in mouse models of B-cell acute lymphoblastic leukemia (B-ALL) and colorectal carcinoma (MC38). Its activity …