Wild-type isocitrate dehydrogenase under the spotlight in
Nov 11, 2021 · IDH1 performs its function in the cytosol, while IDH2 and IDH3 function as part of the tricarboxylic acid (TCA) cycle in the mitochondria. All three IDH isoforms catalyze the …
Targeting Isocitrate Dehydrogenase (IDH) in Solid Tumors: Current ...
Isocitrate dehydrogenase 1 and 2 (IDH1 and IDH2) are essential metabolic enzymes involved in the tricarboxylic acid (TCA) cycle. Several mutations in IDH genes have recently been …
Metabolic alterations due to IDH1 mutation in glioma: opening for ...
Jan 4, 2025 · In cohorts of glioma patients the IDH1 mutation appeared to be a strong predictor of clinical outcome, overruling histological malignancy grade [2]. IDH1 is an enzyme of the …
Wild-type IDH1 Knockout Leads to G0/G1 Arrest, Impairs Cancer …
However, the role of wild-type (wt) IDH1 in the development of colon cancer is still unknown. Our study investigated the role of the IDH1 enzyme in key hallmarks of colon cancer using various …
Metabolic adaptations in cancers expressing isocitrate …
Dec 12, 2021 · IDH1 and IDH2 point mutations in cancer are heterozygous and occur most frequently at, or closely linked to, their active sites. In IDH1, R132 is the most commonly …
IDH1 mutation inhibits differentiation of astrocytes and glioma …
Owing to D-2HG production, IDH mutations naturally affect the homeostasis of α-KG, a crucial intermetabolite of the tricarboxylic acid (TCA) cycle. However, the role of α-KG homeostasis in …
The roles of IDH1 in tumor metabolism and immunity - PubMed
IDH1 is a key metabolic enzyme for cellular respiration in the tricarboxylic acid (TCA) cycle that can convert isocitrate into α-ketoglutarate (α-KG) and generate NADPH. The reduction of …
Targeting isocitrate dehydrogenase (IDH) in cancer - PubMed
Isocitrate dehydrogenase (IDH) is an essential enzyme for cellular respiration in the tricarboxylic acid (TCA) cycle. Recurrent mutations in IDH1 or IDH2 are prevalent in several cancers …
Cancer-Associated IDH1 Promotes Growth and Resistance to …
May 30, 2017 · We show that genetic and pharmacologic inactivation of IDH1 decreases GBM cell growth, promotes a more differentiated tumor cell state, increases apoptosis in response to …
Pathology Outlines - IDH1 (R132H)
3 days ago · Isocitrate dehydrogenase 1 and 2 (IDH1 and IDH2) are metabolic enzymes that catalyzes the oxidative carboxylation of isocitrate to α ketoglutarate (also known as 2 …