Apr 17, 2015 · Isocitrate dehydrogenase-1 (Idh1) is an important metabolic enzyme that produces NADPH by converting isocitrate to α -ketoglutarate. Idh1 is known to reduce reactive oxygen …

Isocitrate dehydrogenase 1 (NADP+), soluble is an enzyme that in humans is encoded by the IDH1 gene on chromosome 2. Isocitrate dehydrogenases catalyze the oxidative …

Apr 15, 2020 · The neomorphic activity of IDH1 mutant consumes NADPH for NADP + production, which suppresses the detoxification of H 2 O 2. Nrf2-associated gene transcription, such as …

Cytosolic isocitrate dehydrogenase 1 (IDH1) and mitochondrial isocitrate dehydrogenase 2 (IDH2) produce NADPH through conversion of isocitrate into α-ketoglutarate.

We report electrochemical studies with IDH1 that exploit this property to reveal the massive advantage of nanoconfinement to increase the efficiency of multistep enzyme-catalyzed …

Oct 23, 2018 · NADPH regeneration may be limiting for lipogenesis and potentially redox homeostasis in IDH1 -mutant cells, highlighting critical links between cellular biosynthesis and …

Here we report that the isocitrate dehydrogenase IDH1 is the most strongly upregulated NADPH-producing enzyme in glioblastoma (GBM). IDH1 silencing in GBM cells reduced levels of …

IDH1 is a dimeric cytosolic NADP-dependent isocitrate dehydrogenase (EC 1.1.1.42) that catalyzes decarboxylation of isocitrate into alpha-ketoglutarate (Nekrutenko et al., 1998).

Apr 1, 2023 · IDH1 catalyzes the conversion of isocitrate to α-KG is accompanied by the production of NADPH, which has the function of maintaining the balance of cell redox reaction …

Mar 30, 2025 · IDH1 (Isocitrate Dehydrogenase (NADP (+)) 1) is a Protein Coding gene. Diseases associated with IDH1 include Enchondromatosis, Multiple, Ollier Type and Multiple …