To characterize 5hmC in IDH1 mutant gliomas further, we examine 5hmC in a cohort of IDH1 mutant and wild-type high-grade gliomas (HGG) using a quantitative locus-specific approach. …

One attractive proposal is that mutated IDH1 produces a new metabolite, 2-hydroxyglutarate (2HG) , which can inhibit TET proteins potentially leading to altered levels of 5hmC and 5mC …

We therefore evaluated the effect of IDH1 or -2 mutations on histone modifications (H3K4me3, H3K9me3 and H3K27me3), chromatin remodeler ATRX expression, DNA modifications (5 …

Isocitrate dehydrogenase 1 (IDH1) is the most commonly mutated gene in grade II–III glioma and secondary glioblastoma (GBM). A causal role for IDH1 R132H in gliomagenesis has been …

Aug 1, 2012 · Our data suggest that the loss of 5hmC is a frequent event in gliomas, independent of IDH1 mutation, and may be influenced by the nuclear exclusion of TET1 from the nuclei of …

Oct 10, 2016 · In summary, Idh1 R132H mutation led to a global decrease of 5hmC and increase of 5mC, consistent with tumor-promoting effects. mRNA Expression Profiling in Tam-Idh1-KI …

Apr 1, 2015 · 5hmC levels are frequently deregulated in cancer. Mutations in TET2, IDH1, IDH2, FH or SDH lead to decreased levels of 5hmC. Changes in DNA (hydroxy)methylation are an …

Dec 12, 2011 · In brain tumors, 5hmdC showed an even more drastic reduction with levels up to >30-fold lower than in normal brain, but 5hmdC levels were independent of mutations in …

Abnormal histone and DNA methylation are emerging as a common feature of tumors with IDH1 and IDH2 mutations and may cause altered stem cell differentiation and eventual …

Jun 15, 2021 · Mutations in IDH1 or IDH2 are frequent among several cancer types with various tissues of origin; the resultant mutated enzymes have neomorphic activity that leads to …