I-TASSER (Iterative Threading ASSEmbly Refinement) is a hierarchical approach to protein structure prediction and structure-based function annotation. It first identifies structural templates from the PDB by multiple threading approach LOMETS , with full-length atomic models constructed by iterative template-based fragment assembly simulations.

I-TASSER server is an on-line platform that implements the I-TASSER based algorithms for protein structure and function predictions. It allows acedemic users to automatically generate high-quality model predictions of 3D structure and biological function of protein molecules from their amino acid sequences.

The structure alignment between the first I-TASSER model and the top 10 most similar structure templates in PDB.

PREDICTIONCENTER.ORG (2022/12/15): An updated version of I-TASSER, D-I-TASSER, was ranked as the No. 1 server in the 15th CASP experiment, in two categories of protein structure predictions including Multi-domain Targets, Single-domain Targets, and DMFold was ranked as the No. 1 predictor in protein complex structure prediction category (i.e ...

I-TASSER-MTD is a hierarchical protocol to predict structures and functions of multi-domain (MTD) proteins. It first predicts the domain boundaries by FUpred and ThreaDom based on the deep-learning contact-map prediction and multiple threading alignments.

I-TASSER Suite is a package of standalone computer programs, developed for high-resolution protein structure prediction, refinement, and structure-based function annotations. A detailed instruction on how to download and install the Suite can be found at README5.2.txt .

Introduction: I-TASSER-MR is a pipeline designed to determine protein structure by combining I-TASSER and molecular replacement (MR). Starting from the amino acid sequence and X-ray diffraction data, 3D models are first constructed by iterative threading assembly refinement simulation (I-TASSER).

This registration is necessary for you to submit and manage your jobs on the I-TASSER server. Please note, this registration is only for the I-TASSER server but not for the I-TASSER package download which needs a separate registration.

C-I-TASSER (Contact-guided Iterative Threading ASSEmbly Refinement) is a new method extended from I-TASSER for high-accuracy protein structure and function predictions. Starting from a query sequence, C-I-TASSER first generates inter-residue contact maps using multiple deep neural-network predictors, including NeBcon , ResPRE , and TripletRes .

D-I-TASSER (Deep learning-based Iterative Threading ASSEmbly Refinement) is a new method extended from I-TASSER for high-accuracy protein structure and function predictions.