Sep 30, 2024 · Crimean-Congo Hemorrhagic Fever virus (CCHFV) is a tick-borne pathogen that causes severe acute fever disease in humans and requires a biosafety level 4 laboratory for …

Here, we review the mechanisms that control HuR function, its influence on target mRNAs, and how impairment in HuR-governed gene expression programs impact upon different disease …

Mar 14, 2022 · Cell death elicited by viral infection affects the interplay between host and virus. In this study, we identified that HuR, an ‘old’ regulator of apoptosis in cancer, plays a ‘new’ role in …

HuR, an RNA binding protein, is critical for many disease states and is particularly important for cancer survival and resistance to therapeutics. As shown, we highlight three current strategies …

Jan 8, 2018 · In this report, we demonstrate that adenovirus infection induces the relocation of HuR to the cytoplasm of host cells. Analysis using the luciferase-ARE fusion gene and the …

Virus yield from Ago2- or HuR-depleted cells decreased more than 1,000-fold. Upon knockdown of both proteins, virus yield decreased almost a million-fold compared to control cells ( Fig 3E …

Oct 9, 2015 · Here, we identified the mRNA stability factor HuR and the RISC subunit Argonaute 2 (Ago2) as two ITAFs that bind stem-loop II. In contrast to AUF1, HuR and Ago2 promote …

Sep 5, 2015 · HuR is a ubiquitous, RNA binding protein that influences the stability and translation of several cellular mRNAs. Here, we report a novel role for HuR, as a regulator of proteins …

Sep 30, 2024 · Crimean-Congo Hemorrhagic Fever virus (CCHFV) is a tick-borne pathogen that causes severe acute fever disease in humans and requires a biosafety level 4 laboratory for …

Consistent with this, HuR regulated apoptosis induced by infection of encephalomyocarditis or Semliki Forest virus. Collectively, our work identified a suite of proteins that regulate dsRNA …