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Wikipedia
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HSP90AB1 - Wikipedia
Heat shock protein HSP 90-beta also called HSP90beta is a protein that in humans is encoded by the HSP90AB1 gene. [5][6][7] HSP90AB1 is a molecular chaperone. Chaperones are proteins …
Classification
Human HSPs are classified into 5 major groups according to the HGNC:
• HSP70
• DnaJ (HSP40)
• HSPB (small heat shock proteins)… See more
04:18
Using Hsp90 inhibitors in the clinic: what have we learned?
YouTubeecancer679 viewsMar 20, 2015
Co-chaperones
Co-chaperones bind to HSPs and influence their activity, substrate (client) specificity and interaction with other HSPs. For example, the co-chaperone CDC37 (cell division cycle 37) stabilizes the cell cycle regulatory … See more
Isoforms
Human HPS90AB1 shares 60% overall homology to its closest relative HSP90AA1. Murine HSP90AB1 was cloned in 1987 based on homology of the corresponding Drosophila melanogaster gene. See more
Protein structure
HSP90AB1 is active as homodimer, forming a V-shaped structure. It consists of three major domains:
• N-terminal domain (NTD) containing the ATP binding site
• middle domain, primarily responsibl… See more
Wikipedia text under CC-BY-SA license

GeneCards
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HSP90AB1 Gene - GeneCards | HS90B Protein | HS90B …
Mar 30, 2025 · HSP90AB1 is a protein coding gene that encodes a molecular chaperone involved in signal transduction, protein folding and degradation and morphological evolution. It is associated with various diseases, pathways and …
nih.gov
https://pmc.ncbi.nlm.nih.gov › articles
HSP90AB1: helping the good and the bad - PMC
HSP90AB1 (heat shock protein 90 kDA alpha, class B, member 1), also known as HSP90beta, is a member of the large family of HSPs which function as molecular chaperones. Chaperones, by binding to client proteins, support proper protein …
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National Center for Biotechnology Information
https://www.ncbi.nlm.nih.gov › gene
HSP90AB1 heat shock protein 90 alpha family class B member 1
High HSP90B expression is associated with laryngeal carcinoma. The expression level of Hsp90AB1 in lung cancer tissues was significantly higher than that in normal lung tissue and …
Nature
https://www.nature.com › articles
Hsp90ab1 stabilizes LRP5 to promote epithelial–mesenchymal …
Oct 10, 2018 · Here, we hypothesized that Hsp90ab1 promotes GC metastasis, leading to a worse prognosis, by activation of the EMT. We began by investigating the relationship of …
- Author: Huanan Wang, Guangxu Deng, Meiling Ai, Zhijun Xu, Tingyu Mou, Jiang Yu, Hao Liu, Shuang Wang, Guoxin...
- Publish Year: 2019
ScienceDirect
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HSP90AB1: Helping the good and the bad - ScienceDirect
Jan 10, 2016 · HSP90AB1 is a heat shock protein that binds to and stabilizes various client proteins, such as steroid hormone receptors, transcription factors and kinases. It is involved in …
People also ask
What does HSP90AB1 stand for?
HSP90AB1 (Heat Shock Protein 90 Alpha Family Class B Member 1) is a Protein Coding gene. Diseases associated with HSP90AB1 include Larynx Cancer and Bronchitis. Among its related pathways are SARS-CoV-2 Infection and Inflammasomes. Gene Ontology (GO) annotations related to this gene include RNA binding and protein kinase binding.
HSP90AB1 Gene - GeneCards | HS90B Protein | HS90B Antibody
genecards.org
Is HSP90AB1 a pseudogene?
Pseudogenes have been identified on multiple chromosomes. [provided by RefSeq, Dec 2012] HSP90AB1 (Heat Shock Protein 90 Alpha Family Class B Member 1) is a Protein Coding gene. Diseases associated with HSP90AB1 include Larynx Cancer and Bronchitis. Among its related pathways are SARS-CoV-2 Infection and Inflammasomes.
HSP90AB1 Gene - GeneCards | HS90B Protein | HS90B Antibody
genecards.org
Is HSP90AB1 a human gene?
Is expressed in several structures, including branchial arch; central nervous system; eye; jaw; and limb. Human ortholog (s) of this gene implicated in multiple sclerosis. Orthologous to several human genes including HSP90AB1 (heat shock protein 90 alpha family class B member 1). [provided by Alliance of Genome Resources, Feb 2025]
Hsp90ab1 heat shock protein 90 alpha (cytosolic), class B member 1
ncbi.nlm.nih.gov
Does HSP90AB1 depend on HSF1?
HSF1 (heat shock factor 1), which binds to HSEs (heat shock elements), is thought to be the major transcription factor for HSPs (Ciocca et al., 2013). However, the basal level of HSP90AB1 transcripts does not depend on HSF1 since HSF1 knockout leads to no transcript reduction in a model of oocytes (Metchat et al., 2009).
HSP90AB1: Helping the good and the bad - ScienceDirect
sciencedirect.com
Where is HSP90B1 located?
Whereas HSP90AA1 and HSP90AB1 are located primarily in the cytoplasm of the cells, HSP90B1 can be found in the endoplasmic reticulum and Trap1 in mitochondria. Co-chaperones bind to HSPs and influence their activity, substrate (client) specificity and interaction with other HSPs.
HSP90AB1 - Wikipedia
en.wikipedia.org
Does HSP90AB1 increase heat tolerance?
SNPs in HSP90AB1 in Thai native cattle are associated with increased heat tolerance (Charoensook et al., 2012). A study on a Turkish population found significantly more polymorphisms in HSP90AA1, HSP90AB1 and HSP90B1 in patients with non-small cell lung cancer (NSCLC) (Coskunpinar et al., 2014). 16. Role in molecular evolution
HSP90AB1: Helping the good and the bad - ScienceDirect
sciencedirect.com
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National Center for Biotechnology Information
https://www.ncbi.nlm.nih.gov › gene
HSP90AB1 heat shock protein 90 alpha family class B member 1 …
Title: HSP90AB1 Promotes the Proliferation, Migration, and Glycolysis of Head and Neck Squamous Cell Carcinoma. LncRNA RP3-326I13.1 promotes cisplatin resistance in lung …
National Center for Biotechnology Information
https://www.ncbi.nlm.nih.gov › gene
Hsp90ab1 heat shock protein 90 alpha (cytosolic), class B member …
Feb 8, 2025 · Data show that the heat shock protein 90 (HSP90) isoforms HSP90AA1 and HSP90AB1 are responsible for maintaining proper cellular levels of BMAL1 protein. Reveal an …
UniProt
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UniProt
Jan 23, 2007 · HSP90AB1-CDC37 chaperone complex interacts with inactive MAPK7 (via N-terminal half) in resting cells; the interaction is MAP2K5-independent and prevents from ubiquitination and proteasomal degradation …
National Center for Biotechnology Information
https://www.ncbi.nlm.nih.gov › gene
hsp90ab1 heat shock protein 90, alpha (cytosolic), class B member …
Predicted to enable several functions, including ATP binding activity; ATP hydrolysis activity; and receptor ligand inhibitor activity. Acts upstream of or within blood vessel development and …
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