Heat shock protein HSP 90-alpha is a protein that in humans is encoded by the HSP90AA1 gene. [5][6] The gene, HSP90AA1, encodes the human stress-inducible 90-kDa heat shock protein alpha (Hsp90A).

Hsp90 (heat shock protein 90) is a chaperone protein that assists other proteins to fold properly, stabilizes proteins against heat stress, and aids in protein degradation. It also stabilizes a number of proteins required for tumor growth, which is why …

Aug 29, 2018 · Therefore, targeting HSP90 is an attractive strategy for the treatment of neoplasms and other diseases. This manuscript will review the general structure, regulation and function of HSP90 family and their potential role in pathophysiology. Keywords: GRP94; HSP90; TRAP1; molecular chaperones; pathophysiology; structure and function.

HSP90 proteins take part in essential cellular processes and regulatory pathways like apoptosis, cell cycle control, cell viability, protein folding and degradation, and signalling events. In addition, they induce the adaptive immunity by activation of antigen presenting cells and dendritic cells.

Mar 30, 2025 · HSP90AA1 (Heat Shock Protein 90 Alpha Family Class A Member 1) is a Protein Coding gene. Diseases associated with HSP90AA1 include Hematologic Cancer and Candidiasis. Among its related pathways are Drug-mediated inhibition of ERBB2 signaling and Loss of Nlp from mitotic centrosomes.

We now know that Hsp90α and Hsp90β are both ubiquitously expressed in all cell types but assigned for distinct and irreplaceable functions. Hsp90β is essential during mouse development and Hsp90α only maintains male reproductivity in adult mice. Neither Hsp90β nor Hsp90α could substitute each other under these biological processes.

Mar 26, 2025 · SMYD3 interacts with HSP90A. WASL (N-WASP) interacts with HSPCA (HSP90-alpha).

Heat shock protein 90 (Hsp90) is a well-characterized, conserved and essential chaperone protein in eukaryotes. Several cellular proteins, termed ‘clients’, rely on Hsp90 for their function.

Jan 28, 2020 · Here, we report a crucial role of HSP90A at the crossroads between NANOG-TCL1A axis and multi-aggressive properties of immune-edited tumor cells by identifying HSP90AA1 as a NANOG transcriptional...

Jan 28, 2020 · Here, we report a crucial role of HSP90A at the crossroads between NANOG-TCL1A axis and multi-aggressive properties of immune-edited tumor cells by identifying HSP90AA1 as a NANOG transcriptional target.