Hypoxia-inducible factor 1-alpha, also known as HIF-1-alpha, is a subunit of a heterodimeric transcription factor hypoxia-inducible factor 1 that is encoded by the HIF1A gene. [5] [6] [7] …

Mar 30, 2025 · HIF1A (Hypoxia Inducible Factor 1 Subunit Alpha) is a Protein Coding gene. Diseases associated with HIF1A include Pheochromocytoma and Retinal Ischemia. Among its …

Recently, it has been identified that hypoxia-inducible factor-1 alpha (HIF-1α) is a major transcriptional regulatory factor that responds to hypoxic environments and modulates the …

Hypoxia-inducible factor-1 (HIF-1) has been recognized as an important cancer drug target. This review summarizes the role and regulation of the HIF-1 α in cancer and recent therapeutic …

Feb 15, 2008 · In keeping with the complexity of the hypoxic response, three principal isoforms of HIF- α exist (HIF-1 α, HIF-2 α and HIF-3 α). All are encoded by distinct gene loci and further …

HIF-1α can function as a multifunctional supplement for hypoxia since it regulates hypoxic genes and the environment, including angiogenesis, erythropoiesis, and glycolysis [3].

HIF1A promotes miR-210/miR-424 transcription to modulate the angiogenesis in HUVECs and HDMECs via sFLT1 under hypoxic stress. HIF-1alpha and Nrf2 regulates hypoxia induced …

Sep 1, 1998 · The HIF1A gene encodes the HIF-1alpha subunit of hypoxia-inducible factor 1, a transcription factor that is essential for cardiovascular development and systemic O2 …

Jul 21, 2016 · Hypoxia-inducible factor-1α (HIF-1α) is a key transcription factor in cellular responses to hypoxia. We investigated the hypothesis that HIF-1α has effects on macrophage …

Jun 9, 2023 · HIF-1α regulates the immune response, viability, migration, phenotypic plasticity, and metabolism of macrophages. Specifically, macrophage-derived HIF-1α can prevent …