CDK4 protein is degraded by anaphase-promoting …
Here, we show that CDK4 protein is degraded by anaphase-promoting complex/cyclosome (APC/C) during metaphase-anaphase transition in HeLa cells, whereas its main regulator, …
CDK4 protein is degraded by anaphase-promoting complex
Jun 16, 2017 · Here, we show that CDK4 protein is degraded by anaphase-promoting complex/cyclosome (APC/C) during metaphase-anaphase transition in HeLa cells, whereas its …
- Author: Huabo Chen, Xiaowei Xu, Guopeng Wang, Boyan Zhang, Gang Wang, Guangwei Xin, Junjun Liu, Qing Jiang, ...
- Publish Year: 2017
Cdk4 and Cdk6 Couple the Cell-Cycle Machinery to …
Apr 14, 2020 · Pharmacological inhibition of Cdk4/6 leads to a rapid, TSC2-dependent reduction of mTORC1 activity in multiple human and mouse cell …
- Author: Jesús Romero-Pozuelo, Gianluca Figlia, Gianluca Figlia, Oguzhan Kaya, Ana Martin-Villalba, Aurelio A...
- Publish Year: 2020
CDK4: a master regulator of the cell cycle and its role in cancer
This review discusses the role that CDK4 plays in cell cycle control, normal development and tumorigenesis as well as the current status and utility of approved small molecule CDK4/6 …
A Cyclin D-Cdk4 Activity Required for G2 Phase Cell
May 14, 1999 · Here we report that in UV-irradiated HeLa and A2058 cells, p16 bound Cdk4 and Cdk6 complexes with increased avidity and inhibited a cyclin D3-Cdk4 complex normally …
- Author: Brian G. Gabrielli, Boris Sarcevic, Joanne Sinnamon, Graeme Walker, Marina Castellano, Xue-Qing Wang...
- Publish Year: 1999
Here, we show that CDK4 protein is degraded by anaphase-promoting complex/cyclosome (APC/C) during metaphase-anaphase transition in HeLa cells, whereas its main regulator, …
- People also ask
CDK4 is degraded by APC/C in mitosis and …
Apr 26, 2017 · Here, we show that CDK4 protein is degraded by APC/C during metaphase-anaphase (M-A) transition in HeLa cells, whereas its main regulator cyclin D1 remains intact but is sequestered in cytoplasm.
CDK4 protein is degraded by anaphase-promoting …
CDK4 regulates G1/S phase transition in the mammalian cell cycle by phosphorylating retinoblastoma family proteins. However, the mechanism underlying the regulation of CDK4 activity is not fully understood. Here, we …
CDK4/6 regulate lysosome biogenesis through TFEB/TFE3
Here, we report that the cyclin-dependent kinases CDK4/6 regulate lysosome biogenesis during the cell cycle. Chemical or genetic inactivation of CDK4/6 increases lysosomal numbers by activating the lysosome and autophagy …
Targeting the AKT/GSK3β/Cyclin D1/Cdk4 Survival …
Jun 1, 2011 · We found that cyclin D1/Cdk4 is a major target of the AKT signaling pathway to suppress tumor radioresistance acquired by fractionated RT. HeLa, a cervical cancer cell line, and HepG2, a human liver cancer cell line, were …
Related searches for Hela CDK4