The 72-kDa immediate early 1 (IE1) protein (called IE1-72kDa, IE72, or IE1) is a nuclear regulatory phosphoprotein of human cytomegalovirus (hCMV), the prototypic betaherpesvirus. …

In this review, we will summarize the documented biological functions of IE1 and pp71 proteins, especially with regard to how they counteract cellular intrinsic defenses.

Aug 9, 2021 · To ensure the success of lytic replication, the herpesvirus human cytomegalovirus (HCMV) expresses the immediate-early protein IE1, which acts as an antagonist of antiviral, …

IE1 is proposed to antagonize the type I IFN-mediated antiviral host cell response by at least two distinct mechanisms. The first mechanism depends on binding of IFN-activatable STAT2 to the …

Jul 7, 2016 · These results suggest an unanticipated dual role for IE1 in either promoting or limiting hCMV propagation and demonstrate how a key viral regulatory protein merges two …

Jun 23, 2021 · As genetic depletion of IFIT1 strongly enhances HCMV growth, and in vitro IFIT1 citrullination impairs its ability to bind to 5’-ppp-RNA, we propose that viral-induced IFIT1 …

Jun 1, 1997 · The major immediate-early (MIE) gene products of human cytomegalovirus (HCMV) are nuclear phosphoproteins that are thought to play key roles in initiating lytic cycle gene …

Jul 27, 2017 · Our study suggests a novel mechanism linking downregulation of Hes1 protein to neurodevelopmental disorders caused by HCMV infection. Our findings also complement the …

Three crucial hurdles hinder studies on human cytomegalovirus (HCMV): strict species specificity, differences between in vivo and in vitro infection, and the complexity of gene regulation. Ever …

May 1, 2013 · We show that the HCMV 72-kDa immediate-early 1 (IE1) protein associates with STAT3 and is necessary to localize STAT3 to the nucleus during infection. Furthermore, …