EP300 - Wikipedia
p300 HAT functions as histone acetyltransferase [6] that regulates transcription via chromatin remodeling, and is important in the processes of cell proliferation and differentiation. It …
p300-CBP coactivator family - Wikipedia
The p300-CBP coactivator family in humans is composed of two closely related transcriptional co-activating proteins (or coactivators): p300 (also called EP300 or E1A binding protein p300) …
CBP/p300 HAT maintains the gene network critical for β cell
May 12, 2021 · Loss of β cell identity and functional immaturity are thought to be involved in β cell failure in type 2 diabetes. CREB-binding protein (CBP) and its paralogue p300 act as …
Histone acetyltransferase - Wikipedia
The p300/CBP HATs have larger HAT domains (about 500 residues) than those present in the GNAT and MYST families. [7] They also contain a bromodomain as well as three …
Transcription factor dimerization activates the p300 ... - Nature
Oct 15, 2018 · We describe a crystal structure of p300 in which the autoinhibitory loop invades the active site of a neighbouring HAT domain, revealing a snapshot of a trans -autoacetylation …
Structural insights into p300 regulation and acetylation ... - Nature
Dec 15, 2022 · We investigate the solution behaviour of the complex and find that interaction with the TAZ2 domain stimulates p300 HAT activity.
Histone acetyltransferases CBP/p300 in tumorigenesis and CBP/p300 …
The CBP/p300 HAT inhibitor C646 down-regulates oncogene expression, reduces acute myeloid leukemia cell clonogenic potential, and induces acute myeloid leukemia cell cycle arrest, …
Histone Acetyltransferases p300 and CBP Coordinate Distinct …
May 3, 2022 · We found that HATs (histone acetyltransferases) p300 and CBP (CREB-binding protein) perform nonoverlapping and opposing roles in vascular smooth muscle cell plasticity.
Live cell studies of p300/CBP histone acetyltransferase activity and ...
Sep 9, 2012 · Additionally, we describe a new p300/CBP HAT inhibitor, C107, and show that it can also increase cellular Histac FRET. Taken together, these studies provide a live cell …
Discovery, Structure-Activity Relationship, and Biological Activity of ...
May 14, 2020 · Histone acetyltransferase (HAT) p300 and its paralog CBP acetylate histone lysine side chains and play critical roles in regulating gene transcription. The HAT domain of …