Hepatocyte nuclear factor 4 alpha (HNF4A) also known as NR2A1 (nuclear receptor subfamily 2, group A, member 1) is a nuclear receptor that in humans is encoded by the HNF4A gene. [5][6] HNF-4α is a nuclear transcription factor that binds DNA as a homodimer.

Mar 30, 2025 · HNF4A (Hepatocyte Nuclear Factor 4 Alpha) is a Protein Coding gene. Diseases associated with HNF4A include Fanconi Renotubular Syndrome 4 With Maturity-Onset Diabetes Of The Young and Maturity-Onset Diabetes Of The Young, Type 1 .

Hepatocyte Nuclear Factor 4alpha (HNF4alpha) Plays a Controlling Role in Expression of the Retinoic Acid Receptor beta (RARbeta) Gene in Hepatocytes. Hepatic nuclear factor 4 alpha promotes the ferroptosis of lung adenocarcinoma via transcriptional activation of cytochrome P450 oxidoreductase.

The HNF4A gene provides instructions for making a protein called hepatocyte nuclear factor-4 alpha (HNF-4α). This protein plays an important role in the function of certain tissues and organs in the body.

Hepatocyte nuclear factor 4-alpha (HNF4α) is a highly conserved member of nuclear receptor superfamily of ligand-dependent transcription factors that is expressed in liver and gastrointestinal organs (pancreas, stomach, and intestine).

HNF4 (H epatocyte N uclear F actor 4) is a nuclear receptor protein mostly expressed in the liver, gut, kidney, and pancreatic beta cells that is critical for liver development. In humans, there are two paralogs of HNF4, HNF4α and HNF4γ, encoded by …

Jan 11, 2022 · Hepatocyte nuclear factor 4A (HNF4A; also designated maturity-onset diabetes of the young 1 (MODY1)) is a transcription factor of the nuclear receptor family that is expressed in multiple...

The hepatocyte nuclear factor-4-alpha (HNF4A) is a member of the nuclear receptor family of transcription factors and is the most abundant DNA-binding protein in the liver, where it regulates genes largely involved in the hepatic gluconeogenic program and lipid metabolism (summary by Chandra et al., 2013).

Hepatocyte nuclear factor 4-alpha (HNF4-α) is a nuclear receptor regulating metabolism, cell junctions, differentiation and proliferation in liver and intestinal epithelial cells. Mutations within the HNF4A gene are associated with human diseases such as maturity-onset diabetes of the young.

Oct 22, 2024 · Hepatic nuclear factor 4 alpha promotes the ferroptosis of lung adenocarcinoma via transcriptional activation of cytochrome P450 oxidoreductase. Besskaya V, Zhang H, Bian Y, Liang J, Bi G, Shan G, Zhan C, Lin ZBesskaya V, et al. PeerJ, 2023. PMID 37180584. HNF4G increases cisplatin resistance in lung adenocarcinoma via the MAPK6/Akt pathway.