HIV tropism refers to the cell type in which the human immunodeficiency virus infects and replicates. HIV tropism of a patient's virus is measured by the Trofile assay. HIV can infect a …

This brief review of recent literature will highlight insight gained from the use of CCR5 inhibitors in clinical trials and relate these results to studies of HIV-1 envelope evolution, CCR5 and …

Viral tropism assays play an important role in identifying patients who are candidates for treatment with entry inhibitors and in the ongoing development of coreceptor inhibitors as a novel class …

The envelope gene of human immunodeficiency virus type 1 (HIV-1) determines the cell tropism of the virus (11, 32, 47, 62), the use of chemokine receptors as cofactors for viral entry (4, 17), …

Feb 17, 2016 · In the early stages of infection, Human Immunodeficiency Virus Type 1 (HIV-1) generally selects CCR5 as the primary coreceptor for entering the host cell. As infection …

Tropism refers to the type of cytokine coreceptor used by HIV-1 when infecting the host cell. The viruses in most (>80%) treatment-naïve patients use the CCR5 (R5) coreceptor. 1 Conversely, …

For HIV-1, the chemokine receptor CCR5 is the predominant co-receptor exploited for transmission and replication in vivo. Variants that switch to use CXCR4 and perhaps other co …

Tropism When HIV selectively attaches to a particular coreceptor on the surface of a host CD4 cell. HIV can attach to either the CCR5 coreceptor (R5-tropic) or the CXCR4 coreceptor (X4 …

Recent findings: The findings that are summarized include resistance to CCR5 inhibitors, genotypic predictors of coreceptor use, the link between coreceptor use and cell tropism, and …

In this review we summarize the molecular basis of viral tropism and its impact on HIV disease progression. Furthermore, we discuss the tools currently available for determining HIV co …