Jan 4, 2024 · In the present study, we investigated the anti-inflammatory properties of Evodiae Fructus 70% ethanol extract (EFE) using activated keratinocytes (HaCaT) and its influences on AD-like skin...

The present study found that Aptamin C suppresses the increase in TARC expression induced by treatment with HDM extract and rIL-22. Aptamin C also effectively suppressed T cell migration that was increased by the culture supernatant of HDM …

Sep 9, 2023 · In this study, the anti-atopic efficacy of FC was demonstrated in HaCaT keratinocytes and HDM-sensitized NC/Nga mice model.

Jun 11, 2021 · Oxidative stress is one of the major causes of inflammatory diseases, including HDM-induced skin inflammation, suggesting that the antioxidant activity of Aptamin C could regulate inflammatory responses to HDMs in the skin keratinocyte cell line HaCaT and primary skin keratinocytes.

To identify the role of HDM in keratinocytes and T cells, we investigated IL-22Rα expression and TARC production in the human keratinocyte cell line HaCaT and IL-22 production in T cells treated with HDM extract as well as their roles in HDM-induced skin inflammation.

Mar 1, 2025 · House dust mite (HDM) allergens can induce or exacerbate allergic inflammation, including atopic dermatitis (AD). Substances that damage the epithelial barrier can trigger or worsen AD. The mechanism by which the novel HDM allergen Der p 39 induces allergic inflammation remains unclear.

May 1, 2012 · We show increased expression of IL-33 and ST2 in AD skin after allergen or staphylococcal enterotoxin B (SEB) exposure, and efficient production of IL-33 by skin fibroblasts, HaCaT keratinocytes, primary macrophages, and HUVEC endothelial cells in response to the combined stimulation of tumor necrosis factor (TNF)-α and IFN-γ.

Results: Both in HaCaT cells and in HDM induced murine model with AD-like lesions, HDM activated TLR1, TLR6, IL-25 and IL-33. Interestingly, knockdown of TLR6 inhibited HDM-induced upregulation of IL-25 or IL-33 mRNA and protein expression in HaCaT cells.

Feb 23, 2016 · To identify the role of HDM in keratinocytes and T cells, we investigated IL‐22Rα expression and TARC production in the human keratinocyte cell line HaCaT and IL‐22 production in T cells treated with HDM extract as well as their roles in HDM‐induced skin inflammation.

Mechanisms involved in induction of TARC/CCL17 synthesis are shown schematically for a human keratinocyte cell lines (HaCaT) and b human monocytes and murine bone marrow–derived macrophages. In HaCaT cells, TNF-α and IFN-γ induce JAK2, p38 MAPK, and Raf-1 activation by phosphorylation after ligation to their dedicated receptors [ 168 , 170 ].