As a member of the class IIa histone deacetylases (HDACs), HDAC9 catalyzes the deacetylation of histones and transcription factors, commonly leading to the suppression of gene transcription. The activity of HDAC9 is regulated transcriptionally and post-translationally.

HDAC9 (histone deacetylase 9) belongs to the class IIa family of histone deacetylases. This enzyme can shuttle freely between the nucleus and cytoplasm and promotes tissue-specific transcriptional regulation by interacting with histone and non-histone substrates.

Histone deacetylase 9 (HDAC9), a member of class II HDACs, regulates a wide variety of normal and abnormal physiological functions. Histones play a critical role in transcriptional regulation, cell cycle progression, and developmental events.

Jun 17, 2020 · Genome-wide association studies have identified a prominent role of HDAC (histone deacetylase)-9 in atherosclerosis and its clinical complications including stroke and myocardial infarction. To determine the mechanisms linking HDAC9 to these vascular pathologies and explore its therapeutic potential for atheroprotection.

Mar 30, 2025 · HDAC9 (Histone Deacetylase 9) is a Protein Coding gene. Diseases associated with HDAC9 include Auriculocondylar Syndrome 4 and Primary Cutaneous T-Cell Non-Hodgkin Lymphoma. Among its related pathways are Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants and Gene expression (Transcription).

Dec 10, 2010 · Histone deacetylase 9 (HDAC9), like most Class II HDACs, catalyzes the removal of acetyl moieties from the ϵ-amino groups of conserved lysine residues in the N-terminal tail of histones.

HDAC9, in cooperation with BRG1 and MALAT1, mediates a critical epigenetic pathway responsible for vascular smooth muscle cells dysfunction. M4 macrophages are a possible source for HDAC9 and MMP12 expression in advanced human carotid plaques.

HDAC9 is a potential novel therapeutic target, and the restoration of aberrant expression patterns observed among HDAC9 target genes and their related signaling pathways may provide opportunities to the design of novel anticancer therapeutic strategies.

Aug 27, 2020 · The HDAC9 (histone deacetylase 9) has been implicated in lipid metabolism, progression of atherosclerosis, and macrophage polarization via alterations in histone acetylation at target genes. 2,3 Genome-wide association studies revealed several genetic variants in the HDAC9 locus are associated with multiple vascular diseases, including ...

Mar 11, 2025 · HDAC9, encoding the signal-responsive histone deacetylase 9 (HDAC9), is a major risk locus for myocardial infarction, stroke, and other vascular disorders.