Histone deacetylase 7 (HDAC7) is a lysine deacetylase and scaffolding protein that regulates numerous cellular and developmental processes via its multifaceted roles in signal transduction and gene regulation.

HDAC7 possesses little intrinsic deacetylase activity and therefore requires association with the class I HDAC, HDAC3 in order to suppress gene expression.

Sep 1, 2024 · HDAC complexes play vital roles in the regulation of key biological processes such as transcription, replication, and DNA repair. Moreover, deregulated HDAC complex function is implicated in human diseases including cancer. Therapeutic strategies targeting HDAC complexes are being sought actively.

Histone deacetylases (HDACs) are evolutionary conserved enzymes which operate by removing acetyl groups from histones and other protein regulatory factors, with functional consequences on chromatin remodeling and gene expression profiles.

Here, we demonstrate that several genes encoding histone-modifying enzymes are alternatively spliced downstream of T cell signaling pathways, including HDAC7, a gene previously implicated in controlling gene expression and differentiation in T cells.

A mutation at the C-terminal NES of HDAC7 inhibits myocyte differentiation. To examine whether altered cellular distribution of HDAC7 affects muscle differentiation, we tested the effects of HDAC7 mislocalization on myogenesis. C2C12 cells were stably transfected with wild-type HDAC7 (WT) or HDAC7 mutant expression constructs.

In recent years, HDAC7 has been increasingly studied in the pathogenesis of tumors. Studies that are pertinent have indicated that it has a significant impact on the growth and metastasis of tumors, the formation of the vascular microenvironment, and the emergence of …

Feb 28, 2024 · HDAC7 facilitates β-catenin redistribution to the nucleus by deacetylating β-catenin and inhibiting its phosphorylation, which results in that the nuclear accumulation of β-catenin binds to TCF/LEF to activate related gene expression.

Mar 28, 2023 · Agosto et al. show that alternative splicing of the histone deacetylase HDAC7 in T cells controls its interaction with protein chaperones, resulting in changes to histone modifications and expression of key activation markers.

Mar 30, 2025 · HDAC7 (Histone Deacetylase 7) is a Protein Coding gene. Diseases associated with HDAC7 include Hematologic Cancer. Among its related pathways are Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants and PIP3 activates AKT signaling.