Histone deacetylase inhibitors (HDACi) are used to treat cancer and were shown to induce ER stress/to modulate the UPR, although the exact mechanism is not fully understood and needs further research. Several approaches to monitoring ER stress exist.

Mar 1, 2008 · Several histone deacetylases (HDAC) are involved in estrogen receptor (ER)-mediated gene transactivation, and HDAC inhibitors have been reported to restore sensitivity to antihormonal therapy. The modulation of ER is the most …

In this study, we found that ER +, hormone-independent, tamoxifen-resistant MCF7-TamC3 cells exhibit increased expression of HDAC2, HDAC5, and survivin, but show decreased expression of miR-125a-5p, as compared to the parental tamoxifen-sensitive MCF7 breast cancer cells.

HDAC2 can also interact with Pdx1 at C -terminus [79]. HDAC3 can bind to the C/EBP homologous protein (Chop) and activating transcription factor 4 (Atf3) promoters in response to hyperlipidemia associated with T2DM and can induce apoptosis to β cells by endorsing endoplasmic reticulum (ER) stress [80].

Aug 1, 2021 · HDAC2 specific inhibition enhances the antitumor effects of tamoxifen, an antiestrogen, by modulating ER and PR signaling mediated by HDAC2 in ER and PR positive breast cancer [92].

ER- and C-erbB-2-positive specimens were more likely to present higher HDAC-2 levels than PR-positive or triple-negative specimens. Moreover, there was a strong correlation between stage III (p < 0.001) and histological grade 3 (p = 0.013), and HDAC-2 over-expression.

These results provide the rationale for novel treatment strategies combining class IIa HDAC inhibitors with ER stressors, including proteasome inhibitors, to improve patient outcome in MM.

Jan 26, 2017 · Various chemotherapeutic agents including histone deacetylase (HDAC) inhibitors can induce ER stress to cause cell death in cancers. Some HDAC inhibitors can prevent HDAC from binding to the...

Feb 27, 2024 · We show that hypoxia-activated XBP1s forms a stable repressor protein complex with HDAC2 and EZH2 to suppress ΔNp63α transcription. Notably, H3K27ac is predominantly occupied on the ΔNp63...

In the tumor microenvironment hypoxia and nutrient deprived states can induce endoplasmic reticulum (ER) stress. If ER stress is not relieved, the tumor cells may become apoptotic. Therefore,...