Sep 4, 2009 · S1P specifically bound to the histone deacetylases HDAC1 and HDAC2 and inhibited their enzymatic activity, preventing the removal of acetyl groups from lysine residues …

Here, we report the presence and activity of S1P lyase in the nuclear fractions of lung epithelial cells, and blocking S1P lyase activity with 4-deoxypyridoxine (4-DP), an analog of pyridoxal …

Jun 4, 2019 · Therefore, our data reveals that intra-nuclear SphK2-S1P axis might facilitate the transformation of microglial polarization from M1 to M2 phenotype, which might be intra …

We found that macrophages of COPD individuals differentiated into M1 phenotype, and the expression of S1PR1 increased and HDAC1 decreased. S1PR1 also inhibits the expression of …

Jun 3, 2019 · When present in the nuclei, SphK2 directs binding of S1P to nuclear histone deacetylase 1 (HDAC1) and/or HDAC2 to inhibit DNA synthesis. In the mitochondria, SphK2 …

Jan 5, 2010 · New evidence has demonstrated that the lipid sphingosine-1-phosphate (S1P) inhibits the activity of HDAC1 and HDAC2. Both S1P and sphingosine kinase 2 (SphK2), the …

Oct 1, 2009 · The enzyme that generates S1P, sphingosine kinase 2 (ShpK2) is present in the nucleus in complexes with HDAC1 and HDAC2. Generation of S1P and its binding to HDACs …

Jul 28, 2021 · We found that macrophages from COPD subjects were polarized towards an M1 phenotype with increased S1PR1 and decreased HADC1experssion. S1PR1 also inhibited …

strated to regulate in ammation, we hypothesized that COPD alters macrophage polarization. To test this, we investigated in individuals with COPD the relationship between S1PR1 and …

Sep 4, 2009 · S1P specifically bound to the histone deacetylases HDAC1 and HDAC2 and inhibited their enzymatic activity, preventing the removal of acetyl groups from lysine residues …