Study finds that aging neurons accumulate DNA damage
May 18, 2020 · MIT neuroscientists have discovered that an enzyme called HDAC1 is critical for repairing age-related DNA damage to genes involved in memory and other cognitive functions. …
Aging neurons accumulate DNA damage - Neuroscience News
May 18, 2020 · MIT neuroscientists have discovered that an enzyme called HDAC1 is critical for repairing age-related DNA damage to genes involved in memory and other cognitive functions. …
Histone Deacetylases (HDACs): Evolution, Specificity, Role in ...
Class I mammalian HDACs (HDAC1, HDAC2, HDAC3, and HDAC8) have sequence similarity to Rpd3 [10] protein: a molecule, belonging to Class I HDACs, responsible for the deacetylation …
HDAC1 Regulates Neuronal Differentiation - PMC
Jan 12, 2022 · Our results showed that both HDAC1 and HDAC2 are expressed in all cellular stages during hippocampal neurogenesis. Moreover, we found that deletion of HDAC1 by viral …
HDAC1 Activators Improve DNA Repair in Neurons to Treat …
May 25, 2020 · An enzyme called OGG1 is responsible for repairing this type of oxidative DNA damage, and the researchers found that HDAC1 is needed to activate OGG1. When HDAC1 …
HDAC1 - Wikipedia
Histone deacetylase 1 (HDAC1) is an enzyme that in humans is encoded by the HDAC1 gene. [5] Histone acetylation and deacetylation, catalyzed by multisubunit complexes, play a key role in …
Rapid degradation of histone deacetylase 1 (HDAC1) reveals …
Dec 19, 2024 · Histone Deacetylase 1 (HDAC1) removes acetyl groups from lysine residues on core histones, a critical step in regulating chromatin accessibility. Despite histone …
The histone deacetylase HDAC1 controls dendritic cell ... - Cell Press
Here, we investigate the impact of histone deacetylation on DCs by genetically deleting histone deacetylase 1 (HDAC1) or HDAC2 in hematopoietic progenitors and CD11c-expressing cells.
HDAC1 Regulates Neuronal Differentiation - PubMed
Jan 12, 2022 · Our results showed that both HDAC1 and HDAC2 are expressed in all cellular stages during hippocampal neurogenesis. Moreover, we found that deletion of HDAC1 by viral …
HDAC1 Gene - GeneCards | HDAC1 Protein | HDAC1 Antibody
Mar 30, 2025 · HDAC1 (Histone Deacetylase 1) is a Protein Coding gene. Diseases associated with HDAC1 include Hematologic Cancer and Epilepsy. Among its related pathways are RNA …